Preprints

Created 12 Oct 2026

DNA methylation-based prediction of differentiation state at cell-type resolution reveals an age-associated epigenetic mesenchymal drift

by Teschendorff, A., Tong, H., Guo, X.

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Created 12 Oct 2026

IsoGraph resolves coordinated transcript choice and gene abundance in the aging human brain

by Bennett, A., Johnson, E. K., Benjamin, K. J. M.

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Created 12 Oct 2026

Chain of Structures: Connecting Reasoning and Generation for Protein Design

by Cai, Q., Xu, M., Yan, J., Wang, Z., Liu, Y., Pei, Q., Zhang, Z.

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Created 12 Oct 2026

WarpDemuX-custom - Multiplexed sequence-specific direct RNA sequencing

by Naarmann-de Vries, I., van der Toorn, W., Mishra, S., Blank, M. F., Heid, D., Mueller-Tidow, C., von Kleist, M., Dieterich, C.

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Created 12 Oct 2026

PeTFlow: Flow-Matching Based All-Atom Peptide Design through Side-Chain State Tokenization

by Deng, Q., Xu, M., Chen, H., Lei, J.

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Created 12 Oct 2026

Large-scale pooled selection enables mapping of modifiers of RNAi gene knockdown effects in C. elegans

by Zdraljevic, S., Lee, A., Walter-McNeill, L., Marquez, H., Webster, A. K., Chitrakar, R., Blount, J., Baugh, L. R., Bloom, J. S., Kruglyak, L.

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Created 12 Oct 2026

Robust V(D)J Recombination in the Absence of SA1/2-mediated Chromatin Loops

by Yang, Z., Fu, Y., Mikhova, M., Chen, D., Hebert, C., Ye, A. Y., Lin, X., Williams, T., Hu, H., Ba, Z., Dekker, J., Alt, F. W.

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Created 12 Oct 2026

Capture-(Hi)C analysis with PostChicago: Integrative metaprofiling and quantitative comparison of chromatin interactions

by Krall, S., Blum, B., Smialkovska, V., Oezcan, E., Dachtler, S.-V., Oldfield, G., Feldmann, A.

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Created 12 Oct 2026

FastaLake selects compact metaproteomic databases from large sequence reservoirs by de novo peptide lookup

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Created 12 Oct 2026

Mitochondrial NAD+ import gates neuronal resilience to active SARM1

by Barbar, L., Bhat, A., Chen, S. J., Strickland, A., Schurr, S., Sundali, S., Kim, H., Sasaki, Y., Bloom, A. J., Milbrandt, J., DiAntonio, A.

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