Preprints

Created 24 Sep 2026

MMRi62 induces iron depletion-driven apoptosis through a ferritin-independent mechanism

by Segui, F., Pagnuzzi, M., Antiq, J., Durivault, J., Vial, V., Bogliotti, N., Leray, I., Vucetic, M., Picco, V.

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Created 24 Sep 2026

Activation of vitamin D signaling suppresses platinum-induced ovarian cancer stem cell plasticity

by Metcalfe, T. X., Xanders, S., Kinne, R. A., Rajendran, S., Zhang, S., Hollenhorst, P. C., Gaspar-Maia, A., O'Hagan, H. M., Nephew, K. P.

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Created 24 Sep 2026

Combination of ALK2 and cholesterol targeting agents exploits linked genetic and metabolic dependencies in diffuse midline glioma

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Created 24 Sep 2026

Oxaliplatin and 5-Fluorouracil induce p53-p21-pRb-associated cell cycle arrest and a transient senescence-like phenotype in patient-derived low-grade serous ovarian cancer cells

by Prakash, R., Forgie, B., Goyeneche, A. A., Zorychta, E., Noman, A., Gilbert, L., Telleria, C. M.

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Created 24 Sep 2026

Targeting MAT2A-S-adenosylmethionine (SAM) Axis Attenuates DNA Damage Response and Cancer Stemness to Increase Platinum Sensitivity in Ovarian Cancer

by Zhang, S., Fu, Z., Zhou, Y., Metcalfe, T. X., Vuong, T. T., Brubaker, L. W., Bitler, B. G., O'Hagan, H. M., Nephew, K. P.

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Created 24 Sep 2026

FAST-MaP: Chemical Mapping of RNA Structures Using Primer-less Sequencing

by Verma, J., Blair, H. M., Kladwang, W., Das, R.

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Created 24 Sep 2026

Structure of PCPE-2 in complex with the BMP-1 metalloprotease reveals the molecular basis of its mechanism of inhibition

by Bauer, J., Lagoutte, P., Vaneyck, J., Calvaresi, V., Bettler, E., Dumoulin, M., Moali, C., Carrique, L., Vadon-Le Goff, S. -

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Created 24 Sep 2026

Enhancing the efficacy of siRNA Antibody Oligonucleotide Conjugates (AOCs) through chemical design

by Hayes, O. G., Rädler, J. A., Filipiak, E., Czapik, T., Roudi, S., Ojansivu, M., Saranya Ilamathi, H., Marquant, A., Huang, Y., Wiklander, O. P., Zain, R., Honcharenko, M., EL Andaloussi, S.

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Created 24 Sep 2026

A systematic map of soil invertebrate biodiversity in Canada: Identifying spatial and taxonomic knowledge gaps

by Dharmasiri, M. E., Lindo, Z., Cameron, E. K.

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Created 24 Sep 2026

Whole-community translocation shows high survival potential of pollution-sensitive benthic macroinvertebrate taxa in restored streams.

by Fagbohun, I. R., Allen, D. C., Sweetman, J. N., Hilderbrand, R. H.

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