Preprints

Created 22 Oct 2026

Spatial proximity to AD pathology defines cell-type and genotype-specific characteristics in human AD hippocampus

by Shi, C. H., Zhu, B., Pina-Crespo, J., Chen, W. N., Vo, G. V., Huang, H., Yip, K. Y., Huang, T. Y.

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Created 22 Oct 2026

Sequence-only prediction of VHH nanobody epitopes and paratopes on HER2 with a frozen protein language model ( ESM2) and a structure-derived residue prior

by Babu, D., Pandurangan, S., Agilisium Consulting

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Created 22 Oct 2026

LKOM: Longitudinal Knockoff with Masked Likelihood Ratio for FDR-Controlled Association Discovery

by Hu, Y., Xu, H., Xu, S., Bi, W., Lin, X.

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Created 22 Oct 2026

Epigenomic heterogeneity and spatial organization during human reprogramming

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Created 22 Oct 2026

Chromosome-level genome assembly and transcriptome resource for the medicinal leech Hirudo verbana

by Tomina, Y., Watanabe, T., Yamaguchi, K., Shigenobu, S.

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Created 22 Oct 2026

CD4+ T cell-intrinsic T-bet sustains protective CNS immunity and parasite control during Toxoplasma gondii infection

by Woellner-Santos, D., Zadeii, K., DelVecchio, R., Somenzi, M., Lopez-Yglesias, A.

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Created 22 Oct 2026

Discovery of a brain-penetrant CHI3L1 inhibitor as an oral modulator of neuroinflammation in Alzheimers disease

by Upadhyay, S., Zhang, L., Kaur, B., Calvo-Barreiro, L., Teplova, M., Gabr, M.

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Created 22 Oct 2026

Modelling the human IL6RA Asp358Ala variant in mice: effects on atherosclerosis and abdominal aortic aneurysm

by Takaoka, M., Sharma, R., Lareyre, F., Clement, M., Harrison, J., Masters, L., Lu, Y., Paul, D., Mallat, Z.

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Created 22 Oct 2026

Genome-scale base editing reveals the functional effects of variants in yeast

by Boocock, J., Crisman, L., Alamo Tapia, L. A., Patel, S., Vo, C., Liu, C., Marquez, H., Bloom, J. S., Kruglyak, L. S.

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Created 22 Oct 2026

A sulfur-cycling co-culture alters iron sulfide diagenesis and pyritization

by Santha, K., Duverger, A., Marin-Carbonne, J., Berg, J.

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