Preprints

Created 25 Jul 2026

Chromosome-scale CRISPR screening reveals secretory pathway genes as drivers of aneuploidy-mediated antifungal tolerance

by Gervais, N. C., Wensing, L. F., Chhina, M., Fogal, M., Despres, P. C., Hoyer, L. L., Gerstein, A. C., Shapiro, R. S.

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Created 25 Jul 2026

Microbial Immunomodulatory Function is Altered in Inflammatory Bowel Disease Independent of Microbial Composition

by Giri, R., Teh, J. J., Zhang, F., Reed, H., Hold, G. L., Cuiv, P. O., Morrison, M., Begun, J.

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Created 25 Jul 2026

Network topology determines neuronal phase-of-firing codes

by Pratyush, M. R., Assisi, C.

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Created 25 Jul 2026

Network-scale disruption of RNA-protein interactions by a bioaccumulating small-molecule drug

by Jiang, X., Mozzachiodi, S., Roux, I., Makwana, M., Zhou, W., Villanueva, E., Kamrad, S., Lindell, A., Beristain-Covarrubias, N., Ingole, K. D., Zhang, N., Patel, S. K., Blasche, S., Lilley, K. S., Patil, K. R.

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Created 25 Jul 2026

Metabolic engineering of Escherichia coli to modulate hydrogen sulfide levels in the mammalian gut

by Hayes, J. A., Buchinger, B., Lunger, A. W., Khanvilkar, T., Gasparrini, W., Fernez, M. T., Morrissette, M., Strandwitz, P., Koppes, A. N., Koppes, R., Woolston, B. M.

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Created 25 Jul 2026

Intratumoral dose heterogeneity promotes adaptive anti-tumor immunity and predicts clinical response to radiopharmaceutical therapy

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Created 25 Jul 2026

Machine Learning-Assisted Evolution of Broadly Functional Enzyme Libraries

by Lal, R., Yang, J., Zhang, Z., Arnold, F. H.

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Created 25 Jul 2026

G-quadruplex folding uncouples cis-activation from collateral trans-cleavage by Cas12a

by Safenkova, I. V., Kamionskaya, M. V., Samokhvalov, A. V., Zherdev, A. V., Dzantiev, B. B.

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Created 25 Jul 2026

An Integrated Multi-omics Single Cell Atlas of the Human RPE and Choroid

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Created 25 Jul 2026

Self-supervised representations reveal the genetic architecture of human cortical folding

by Dufournet, A. J., Laval, J., Chavas, J., Fischer, C., Riviere, D., Frouin, V., Mangin, J.-F.

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