Preprints

Created 23 Sep 2026

Zika virus oncolytic signaling reverts immunosuppressive and angiogenic glioblastoma microenvironment in vitro and in vivo

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Created 23 Sep 2026

Nanobody-Functionalized AAV achieves Promoter-independent Neuronal Targeting in the CNS

by Extross, A., Fernandez de Velasco, E. M., He, Y., Wickman, K., Schmidt, D.

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Created 23 Sep 2026

MCT1 activity defines an aggressive metabolic phenotype and therapeutic target in non-small cell lung cancer

by Cameron, R. B., Shema, K. E., Dubois, N., Clare, M. G., Hammond, N. G., Kaur, M., Chang, B. K., Schechter, E. G., Hsiang, J., Marczenia, Z., Garassino, M. C., Cai, L., Bestvina, C. M., Mathews, T. P., Tasdogan, A., Shah, H., Faubert, B.

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Created 23 Sep 2026

A step toward synthetic endosymbiosis: introducing Escherichia coli and the trypanosomatid endosymbiont Candidatus Kinetoplastibacterium crithidii into mammalian cells using a polyethylene glycol-based fusion protocol

by Pednekar, R., van Geelen-Kuenzel, N., Diehl, C. M., Koch, L.-A., Llorente, B., Nowack, E. C. M., Zurbriggen, M. D.

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Created 23 Sep 2026

SWELL1 channel-mediated D-2HG export promotes immune evasion and metabolic fitness in IDH-mutant gliomas

by Cheng, H. Y., Ma, L., Chen, J., Huang, J., Chen, L., Liu, W., Liu, Y., Zhao, R., Ye, Y., Zheng, W., Kratz, L., Castro, M., Sun, S., Zhu, J., Han, L., Qiu, Z.

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Created 23 Sep 2026

Targeting the CDK4-Cyclin D Complex: A New Generation of Selective Kinase Inhibitors for Cancer Therapy

by Fuentes-Baile, M., Encinar, J. A., Araujo-Abad, S., Perez-Valenciano, E., Garcia-Morales, P., Fuertes-Garcia, L., de Juan Romero, C., Saceda, M.

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Created 23 Sep 2026

A tumor-cell MHC-II program is associated with checkpoint-blockade outcomes across stages of bladder cancer

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Created 23 Sep 2026

Noninvasive tomography of tumor progression via dynamical changes of T-cells in surrounding microenvironment

by Xu, L., Meng, P., Yin, W., Liu, H.

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Created 23 Sep 2026

Geometry-dependent mRNA delivery with programmable RNA-DNA nanostructures

by Zheng, M., Dwivedy, A., Gandavadi, D., Hong, W., Cho, H., Shkolnik, N., Wang, X.

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Created 23 Sep 2026

Spatiotemporal Control of Genetic and Epigenetic Editing through Covalent Tethering of CRISPR Nanoparticles to Zwitterionic Microgels

by Graham, J. P., Wheeler, E. E., Leach, K. J., Gonzalez-Fernandez, T.

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