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Created 18 Jul 2026

Iron overload suppresses LKB1 and induces IL36G anti-tumor immunity in PDAC metastasis.

by Douglas E Biancur, Harsha Venkatesh, Amy Crawford, Yealeen Jeong, Albert S W Sohn, Kevin S Kapner, Keisuke Yamamoto, Elaine Y Lin, Robert S Banh, Mohamad Assi, Beny Shapiro, Peter Yu, Soomin C Song, William A Coetzee, Andrew J Aguirre, Alisha N Jones, Alec C Kimmelman, Richard Possemato — Science advances. Volume 12(29): eadz8681. Jul 17, 2026.
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Created 18 Jul 2026

FGF21 induced by endoplasmic reticulum stress maintains medullary thymic epithelial cell function and central immune tolerance.

by Yuki Masuda, Yoshiaki Nakayama, Ryohei Shimizu, Hiroshi Hasegawa, Morichika Konishi — Science advances. Volume 12(29): eaee9999. Jul 17, 2026.
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Created 18 Jul 2026

A distinct antigen presentation pathway drives potent T cell immunity in lipid nanoparticle-based mRNA vaccines.

by Ryunosuke Muro, Suqi Wang, Taku Ito-Kureha, Hung Hiep Huynh, Kouji Kobiyama, Takuya Sugita, Kazuo Okamoto, Kenta Nakano, Tadashi Okamura, Masato Kubo, Ken J Ishii, Takeshi Nitta, Hiroshi Takayanagi — Science advances. Volume 12(29): eaec7827. Jul 17, 2026.
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Created 18 Jul 2026

Linking functional and structural dendritic spine remodeling during fear learning and extinction in vivo.

by Xiaoyang Li, Qiyu Zheng, Kim Hoi Kin Wong, Kenneth Kin Yip Wong, Cora Sau Wan Lai — Science advances. Volume 12(29): eaec3961. Jul 17, 2026.
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Created 18 Jul 2026

Fibroblast-specific ablation of MHC-I antigen presentation via the IGF2 axis cripples CD8⁺ T cell surveillance in lung cancer.

by Daqiang Song, Xiaofang Li, Qian Xiao, Hongtao Tie, Qianxue Wu, Yu Shi, Guomin Ye, Jiazheng Sun, Jiazhou Liu, Mingjing Chen, Zhu Qiu, Weiyan Peng, Long Meng, Guosheng Ren, Jing Huang, Hongzhong Li — Science advances. Volume 12(29): eaee5738. Jul 17, 2026.
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Created 18 Jul 2026

A neurocutaneous Na_V1.8 channelopathy underlies a genetic subtype of primary idiopathic hyperhidrosis.

by Suguru Yamauchi, Jolien Vander Cruyssen, Michele Cervellera, Elizabeth Wohler, Jolien De Waele, Maxime Lammens, Corinne Boehm, Nara L Sobreira, Carley Blevins, Kaitlyn Ecoff, Yuping Mei, Margaux Theys, Ife Shoyombo, Maria Shishikura, Hongrui Yi, Kristen Rodgers, Beverly Lee, Hamza Khan, Andrei Gurau, Wasay Nizam, Shivani Shirodkar, Christine Kim, Joshua Choi, Daniel Coleman, Brooke Dorman, Takumi Iwasawa, Jin U Kang, Yves Heremans, Hajime Orita, Tetsu Fukunaga, Filip Van Petegem, Stephen B Baylin, Andreas S Barth, Tae Hwan Chung, Peter C Rowe, Glenn Treisman, Jinny Ha, Ruslan I Dmitriev, David Valle, Frank Bosmans, Malcolm V Brock — Science advances. Volume 12(29): eaed3221. Jul 17, 2026.
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Created 18 Jul 2026

ALR couples IMS redox and heme biosynthesis beyond the disulfide relay.

by Julia Racho, Dylan Stobbe, Jan Jirschitzka, Marijana Croon, Carmelina Petrungaro, Muna Ali, Dario Wernet, Markus Habich, Nele Sophie Gawellek, Julian Strippel, Finn Dicke, Jörn Dengjel, Stephanie Kath-Schorr, Bent Brachvogel, Thomas Langer, Aleksandra Trifunovic, Ines Neundorf, Jan Riemer — Science advances. Volume 12(29): eaed2430. Jul 17, 2026.
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Created 18 Jul 2026

Varicose projection astrocytes: Conserved reactive cells in brain pathology.

by Caterina Ciani, Giulio Pistorio, Simona Giancola, Marika Mearelli, Francesca Emma Mongelli, Delaram Forouzeh, Luana Campos Soares, Marta Gonzalez Martin, Mandi E Lichtenstein, Luca Mio, Elena Christou, Kyle Hastings, Anh Quynh Nguyen Do, Paula Ramos-Gonzalez, Carlos Matute, Ugne Kuliesiute, Sari Elena Dötterer, Gediminas Luksys, Saulius Rocka, Urte Neniskyte, Daniel C Anthony, Marya Ayub, Cinzia Centelleghe, Maria Angeles Arevalo, Jean-Marie Graïc, Francesco Petrelli, Alexei Verkhratsky, Nunzio Iraci, Fabio Cavaliere, Carmen Muñoz-Ballester, Mootaz M Salman, Francesco P Ulloa Severino, Carmen Falcone — Science advances. Volume 12(29): eady8204. Jul 17, 2026.
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Created 18 Jul 2026

Albumin binding improves the pharmacokinetics and therapeutic efficacy of a ¹⁷⁷Lu-labeled HER2 Fab radioconjugate.

by Peifei Liu, Yizhen Pang, Cuicui Li, Yuqi Hua, Wenyao Zhen, Tianzhi Zhao, Xiaobin Zhao, Jie Liu, Bingyu Li, Jinming Yu, Xiaoyuan Chen, Jingjing Zhang — Science advances. Volume 12(29): eaee4052. Jul 17, 2026.
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Created 18 Jul 2026

Hyperwrinkling of the nuclear lamina is associated with attenuated mechanosensitivity in giant nucleated cancer cells.

by Samere Abolghasemzade, Ryan Blanchard, Chance French, Christina R Dollahon, Harrison Pham, Aidan Atkins, Richard B Dickinson, Tanmay P Lele — Science advances. Volume 12(29): eaed1645. Jul 17, 2026.
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