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Created 11 Sep 2026

Efficacy and safety of mitapivat in adults with transfusion-dependent α-thalassaemia or β-thalassaemia (ENERGIZE-T): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial.

by Maria Domenica Cappellini, Sujit Sheth, Ali Taher, Hanny Al-Samkari, Ali Bülent Antmen, David Beneitez, Giovanna Cannas, Thomas Coates, Lauren Czapla, Jayme L Dahlin, Jeremie H Estepp, Elizabeth Feenstra, Pencho Georgiev, Sarah Gheuens, Gavrielle M Price, Andreas Glenthøj, Khaled M Musallam, Kareem Osman, John B Porter, Hui Shao, Katrin Uhlig, Eduard J van Beers, Vip Viprakasit, Kevin H M Kuo, Antonis Kattamis, ENERGIZE-T Investigators — Lancet (London, England). Volume 408(10559): 1010-1018. Sep 12, 2026.
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Created 11 Sep 2026

Naming palliative care in conflict and forced displacement.

by Matthew J Allsop, Olena Riga, Mohamed Reyad Zughbur, Eve Namisango, Donald R Sullivan, Gemma Bowsher, Mac Skelton, Hibah Osman, William E Rosa — Lancet (London, England). Volume 408(10559): 996-997. Sep 12, 2026.
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Created 11 Sep 2026

Long-term outcomes of top-down therapy versus a conventional step-up strategy in adults newly diagnosed with Crohn's disease: 5-year follow-up of the PROFILE trial.

by Nurulamin M Noor, Mohmmed Tauseef Sharip, Haiyan Zheng, Barry Widmer, Biljana Brezina, Kamal V Patel, Francis Dowling, Suhaylah Bhatti, Nadia Alsmade, Tariq Ahmad, Paul J Banim, James W Berrill, Rachel Cooney, Juan De La Revilla Negro, Shanika de Silva, Shahida Din, Dharmaraj Durai, John N Gordon, Ailsa L Hart, Peter M Irving, Matthew Johnson, Alexandra J Kent, Klaartje B Kok, Gordon W Moran, Craig Mowat, Pritash Patel, Tim Raine, Rebecca Saich, Dan Sharpstone, Melissa A Smith, Alan Steel, Sreedhar Subramanian, Alan Wiles, Horace R T Williams, James O Lindsay, Nicholas A Kennedy, Eoin F McKinney, Paul A Lyons, Kenneth G C Smith, James C Lee, David S Robertson, Miles Parkes, PROFILE Study Group — The lancet. Gastroenterology & hepatology. Sep 10, 2026.
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Created 11 Sep 2026

Intracavitary electron radiotherapy with dynamic shielding for rectal cancer: applicator design and dosimetric characterization.

by Jinghui Wang, Mingqing Wang, Heming 鹤茗 Wang 王, Jianfeng Lv, Bin Liu, Qiheng Li, Dongna Li, Da Fu, Kai Wang, Dongpo Fu, Hanxiang Du, Xin Xia, Bo Ma, Chaohui Ran, Wenbin Yan, Wei Gai, Kun Zhu, Hao Wang, Xueqing Yan — Physics in medicine and biology. Sep 10, 2026.
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Created 11 Sep 2026

Linking cellular metabolism to mitochondrial outer membrane potential.

by Kaitlin Abrantes, Bethel G Beyene, Nina A Bautista, Wendy Fitzgerald, Tatiana K Rostovtseva, Sergey M Bezrukov, Megha Rajendran — Mitochondrion. Pages 102218. Sep 10, 2026.
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Created 11 Sep 2026

PD16, a steroidal saponin, induces apoptosis in colorectal cancer via inhibiting the AKT/GSK3β signaling pathway.

by Minna Yao, Wei Zhang, Dong Xu, Likun Ding, Ya Bai, Ruili Li, Kai Gao, Xian Zhao, Huan Dang, Ning Ma, Yuan Li, Weiwei Li, Haifeng Tang, Yi Ding — European journal of pharmacology. Pages 179340. Sep 10, 2026.
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Created 11 Sep 2026

Targeting lipid metabolism-associated lncHMGCS1 suppressed cell proliferation and restored intracellular lipid homeostasis by regulating ACSL3 in gastric cancer.

by Qiang Yang, Yuyang He, Lejia Wang, Xiaoxia Yuan, Jingping Zhang, Jinxin Chen, Guohui Jiang, Wenrong Ma, Xingtong Lu, Chen Wei, Bin Zhang, Shihao Deng, Yaomin Luo, Yang Xiao, Kexun Long, Chaoying Xu, Xinqiang Yin, Zhen Jiang — European journal of pharmacology. Pages 179339. Sep 10, 2026.
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Created 11 Sep 2026

Vascular Surgical Tips for Sacral Tumor Surgery: A Practical Narrative Review.

by Fernando Padilla-Lichtenberger, Federico Landriel, Gustavo Giraldo, William G J Teixeira, Alfredo Guiroy, Jean-Paul Wolinsky, Tianyi Niu, Ziya Gokaslan, Justin E Bird, Laurence D Rhines, Julio J Jauregui, Daniel Sciubba, Santiago M Hem — World neurosurgery. Pages 125315. Sep 10, 2026.
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Created 11 Sep 2026

Empowering Oocyte Autonomy: A Critical Exploration of Choice in Fertility Preservation.

by Orestis Tsonis, Julia Kopeika — Journal of gynecology obstetrics and human reproduction. Pages 103278. Sep 10, 2026.
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Created 11 Sep 2026

Co-occurrence of bronchiolar adenoma and lung adenocarcinoma: a study of nine cases revealing distinct clonal origins via integrated histologic, immunophenotypic and molecular analysis.

by Shaoling Li, Yan Huang, Zhengwei Dong, Junhong Guo, Wei Wu, Likun Hou, Quan Li, Chunyan Wu — Human pathology. Pages 106261. Sep 10, 2026.
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