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Created 10 Oct 2026

PI3Kδ is selectively inhibited by roginolisib by stabilizing the C-terminal helix kα12.

by Oscar Vadas, Simon Tiede, Maria Chaouki, Laura Tesmer, Shanlin Rao, Rémy Visentin, Ulrich Grädler, Martin Augustin, Reiner Kiefersauer, Carola Gößer, Anne Quillet-Mary, Loïc Ysebaert, Julie Guillermet-Guibert, Lars van der Veen, Giusy Di Conza, Gerhard Hummer — Nature communications. Volume 17(1). Oct 09, 2026.
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Created 10 Oct 2026

Predicting the clinical course of advanced systemic mastocytosis on treatment with avapritinib or midostaurin.

by Johannes Lübke, Jason Gotlib, Daniel J DeAngelo, Juliana Schwaab, Deepti H Radia, Michael Deininger, Tracy I George, Ilda Bidollari, Saša Dimitrijević, Javier I Muñoz-González, Hongliang Shi, Andreas Reiter — Leukemia. Oct 09, 2026.
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Created 10 Oct 2026

RUNX1 aberrations in blast-phase chronic myeloid leukaemia induce the RNA-binding protein SPATS2L, which promotes growth, survival and stress granule assembly.

by D A Palmer, D Ogilvie-Park, A L Muir, R Craig, O Sevim, L Stott, A Kakkar, P A Lewis, M Wilson, K Heesom, G A Horne, M Copland, S Mustjoki, S Adnan-Awad, K Porkka, S Jain, N Bayat, D Famili, H Webb, M J West, F K Mardakheh, T Chevassut, A Tonks, S G Kellaway, B P Towler, R G Morgan — Leukemia. Oct 09, 2026.
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Created 10 Oct 2026

Bone health in myelodysplastic neoplasms: results from the prospective longitudinal BoHemE study.

by Heike Weidner, Elena Tsourdi, Anne Sophie Platzbecker, Martina Rauner, Ulrike Baschant, Maria G Ledesma-Colunga, Karolina Basiak, Katja Sockel, Ekaterina Balaian, Susann Winter, Anna Harig, Klaus H Metzeler, Katharina S Götze, Dominic Brauer, Nicole Modler, Michael Cross, Marie Schneider, Jörg Lützner, Andreas Roth, Thomas Zerjatke, Gabriele Müller, Uwe Platzbecker, Lorenz C Hofbauer — Leukemia. Oct 09, 2026.
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Created 10 Oct 2026

Mitochondria transfer via tunneling nanotubes drives macrophage immunosuppression and metabolic reprogramming in pediatric AML.

by Alicia Perzolli, Farah Massaoudi, Anita T van Oort, Joost B Koedijk, Elizabeth K Schweighart, Lennart A Kester, Fabienne Adriaanse, Kimberly Smit, Wilbert P Vermeij, Bianca F Goemans, Josef Vormoor, C Michel Zwaan, Olaf Heidenreich — Leukemia. Oct 09, 2026.
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Created 10 Oct 2026

BCR signal strength governs VH gene replacement in peripheral B cells.

by Monika Vashisht, Huaibin Ge, Karen Siddoway, Jessy John, Harlie A McKelvey, Rui Dong, Mohammad A I Al-Hatamleh, Alexandra Krinsky, Vince Popolizio, Alondra M Ware, Gero Knittel, Hans Christian Reinhardt, Zhangguo Chen, Jing H Wang — Cellular & molecular immunology. Oct 09, 2026.
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Created 10 Oct 2026

A modular framework for antibody-drug conjugate biomarkers.

by Jia Liu, Dan-Yun Ruan, Nicholas McNamee, Roger R Reddel, Hao-Xiang Wu, Qi Meng, Rui-Hua Xu, Vivek Subbiah, David L Rimm, Barbara Pistilli — Nature reviews. Clinical oncology. Oct 09, 2026.
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Created 10 Oct 2026

Author Correction: The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4⁺ T cells by preventing ferroptosis.

by Yifei Wang, Qin Tian, Yaxing Hao, Wei Yao, Jinjin Lu, Cheng Chen, Xiangyu Chen, Yao Lin, Qizhao Huang, Lifan Xu, Jianjun Hu, Shun Lei, Zhengping Wei, Yuan Luo, Zhirong Li, Li Hu, Jianfang Tang, Qing Wu, Xinyuan Zhou, Yuzhang Wu, Zhinan Yin, Jianqing Xu, Lilin Ye — Nature immunology. Oct 09, 2026.
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Created 10 Oct 2026

The GMALL B ALL/NHL 2002 protocol yields high rates of durable response in high grade B cell lymphoma.

by Silvia Ferrari, Francesco Ballardini, Andrea Rossi, Anna Grassi, Chiara Pavoni, Monica Rondi, Paolo Fruscella, Andrea Gianatti, Giuseppe Gritti, Anna Maria Barbui, Federico Lussana, Alessandro Rambaldi — Blood cancer journal. Volume 16(1). Oct 09, 2026.
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Created 10 Oct 2026

A novel substrate for CYP3A4 phenotyping: in vitro biotransformation of hubamine into butanone.

by Rebecca Hofer, Valentina Stock, Klaus R Liedl, Jakob Troppmair, Christian Dank, Thierry Langer, Hubert Gstach, Sarah Kammerer, Veronika Ruzsanyi — Analytical and bioanalytical chemistry. Oct 09, 2026.
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