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Created 11 Jul 2026

The MEK inhibitor trametinib incurs mitochondrial injury and induces innate immune responses in the mouse heart.

by Kelsey H Fisher-Wellman, Richard D Lutze, Logan G Kirkland, Ju Youn Beak, Mansi Goyal, Raghu Nagalingam, Samantha M Morrissey, Peyton B Sandroni, Wei Huang, Julian D Bailon, Melissa A Schroder, Lars A Albrecht, Ethelyn Ofei, Andrew L Chin, Thomas D Green, Joseph M McClung, McLane M Montgomery, James T Hagen, Brett R Chrest, Edziu M Franczak, Polina Krassovkaia, Raphael T Aruleba, Jon S Zawistowski, Timothy J Stuhlmiller, Shawn M Gomez, Nanthip Prathumsap, Qing Zhang, Jing Zhang, Weiyi Xu, Lilei Zhang, Jeremy A Meier, Lisa A Carey, Jonathan C Schisler, Gary L Johnson, Brian C Jensen — Science advances. Volume 12(28): eaeb2695. Jul 10, 2026.
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Created 11 Jul 2026

G protein selectivity in group I metabotropic glutamate receptors.

by Yue Lu, Tianlei Wen, Xuhang Lu, Guimin Zhang, Tingting Meng, Tianjin Liu, Xinyan Wang, Yuequan Shen, Xue Yang — Science advances. Volume 12(28): eaee0044. Jul 10, 2026.
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Created 11 Jul 2026

Modeling human embryo adhesion using a microfluidic platform.

by Sofía Zaragozano, María Pardo-Figuerez, Ana Monteagudo-Sanchez, Anna Quirant, Javier Moncayo-Arlandi, Javier Gonzalez-Fernandez, Jaime Llera-Oyola, Petr Volkov, Sara Maggi, Luis Quintero, Francisco Raga, Pablo Grases, Xavier Santamaria, Inmaculada Moreno, Nicolas Plachta, Carlos Simon, Felipe Vilella — Science advances. Volume 12(28): eadz2249. Jul 10, 2026.
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Created 11 Jul 2026

Low-intensity stimulation drives macrophage efferocytosis via ACSL4 lipid remodeling and CCL9-CCR1 signaling for tendon-bone healing.

by Juncheng Yao, Yuhao Wu, Xuan Wang, Jiexin Zhang, Yan Shao, Huabin Chen, Haiyan Zhang, Haobin Li, Jianying Pan, Yitao Zhao, Daozhang Cai, Denghui Xie, Chun Zeng — Science advances. Volume 12(28): eadw6666. Jul 10, 2026.
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Created 11 Jul 2026

Direct visualization of native GSDMD pores reveals lipid-driven stabilization during pyroptosis.

by Shirin Kappelhoff, Michael Holtmannspötter, Stefan L Schaefer, Eleonora G Margheritis, Özgün Doga Asik, Nadine Gehle, Hannah Veit, John S H Danial, Rico Franzkoch, Sebastian Strauss, Jonatan Alvelid, Agnes Koerfer, Christian Eggeling, Olympia E Psathaki, Ralf Jungmann, Rainer Kurre, Gerhard Hummer, Jacob Piehler, Katia Cosentino — Science advances. Volume 12(28): eaee4587. Jul 10, 2026.
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Created 11 Jul 2026

Unconventional vesicle transport driven by formin-actin-myosin working system during pollen germination.

by Tonghui Li, Chang Liu, Tongtong Shen, Bo Li, Qi Wang, Zhe Zhu, Xuna Wu, Ting Wang, Huimin Wang, Haiyun Ren — Science advances. Volume 12(28): eaeb7188. Jul 10, 2026.
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Created 11 Jul 2026

A prolactin-receptive neural circuit drives maternal interactions with pups in mice.

by Jenny Clarkson, Michael R Perkinson, Tapasya Pal, Isaiah Cheong, H James McQuillan, Judith M Swart, Joon S Kim, Emmet M Power, David R Grattan, Rosemary S E Brown — Science advances. Volume 12(28): eady6498. Jul 10, 2026.
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Created 11 Jul 2026

Multicellular simulations with shape and volume constraints using optimal transport.

by Antoine Diez, Jean Feydy — Science advances. Volume 12(28): eadv2781. Jul 10, 2026.
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Created 11 Jul 2026

Epigenetic landscape, key transcriptional regulators, and in vivo identification of human Tr1 cells.

by Alma-Martina Cepika, Laura Amaya, Colin Waichler, Mansi Narula, Michelle Mantilla, Benjamin C Thomas, Pauline P Chen, Robert A Freeborn, Mara Pavel-Dinu, Jason Nideffer, Matthew Porteus, Rosa Bacchetta, Fabian Müller, William J Greenleaf, Howard Y Chang, Maria Grazia Roncarolo — Science advances. Volume 12(28): eaec6358. Jul 10, 2026.
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Created 11 Jul 2026

Submicromolar imaging of intrinsic chromophores by two-photon photothermal microscopy captures mitochondrial response to chemotherapy.

by Nathaniel Hai, Chinmayee Vallabh Prabhu Dessai, Dingcheng Sun, Jianpeng Ao, Pin-Tian Lyu, Yifan Zhu, Ji-Xin Cheng — Science advances. Volume 12(28): eaee7678. Jul 10, 2026.
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