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Created 10 Sep 2026

Structure-Based Design of First Ndc80 Loop-Targeting Peptide Disrupting Ndc80-Nuf2 Interaction for Hepatocellular Carcinoma Therapy.

by Xing Jin, Miao-Miao Niu, Yifei Geng, Liqiao Han, Yuting Wang, Xianzhang Huang, Qiaoxuan Zhang — Journal of medicinal chemistry. Volume 69(17): 20877-20893. Sep 10, 2026.
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Created 10 Sep 2026

Keggin-Type Polyoxometalates as a Systematic Antiviral Scaffold: Activity, Cytotoxicity, and Solution Stability across Heteroion and Addenda Metal Variations.

by Judith Füllborn-Ott, Aliona Dobrova, Nadiia I Gumerova, Ingo Ott, Annette Rompel — Journal of medicinal chemistry. Volume 69(17): 20772-20781. Sep 10, 2026.
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Created 10 Sep 2026

Optimization of a Series of Novel 1H-Pyrrolo[3,2-c]pyridine-Based USP1 Inhibitors with Potent In Vivo Antitumor Activity.

by Tao Yang, Xue Cui, Qingyan Li, Yaxin Teng, Minghai Tang, Xinyu Zou, Xiaobo Cen, Lijuan Chen, Min Zhao, Linyu Yang, Zhuang Yang — Journal of medicinal chemistry. Volume 69(17): 20403-20432. Sep 10, 2026.
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Created 10 Sep 2026

Discovery of Highly Efficacious CRBN-Based KRAS Degraders Targeting Cancers with KRAS G12D and G12V Mutations.

by Changwei Wang, Prithwish Ghosh, Shicheng Jin, Longchuan Bai, Angelo Aguilar, Donna McEachern, Mi Wang, Qiuxia Li, Bo Wen, Duxin Sun, Shaomeng Wang — Journal of medicinal chemistry. Volume 69(17): 20520-20539. Sep 10, 2026.
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Created 10 Sep 2026

Rapid Two-Step Multicomponent Synthesis and Structure-degradation Relationships of Selective HDAC6 PROTAC Degraders.

by Mikhail Tsymliakov, Maria Hanl, Jana Enns, Shiyang Zhai, Eleonora Ferretti, Philipp König, Rama Kousa, Jia-Wey Tu, Christian Steinebach, Michael Gütschow, Gerd Bendas, Sanil Bhatia, Günther Weindl, Finn K Hansen — Journal of medicinal chemistry. Volume 69(17): 21018-21043. Sep 10, 2026.
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Created 10 Sep 2026

Macrocyclization of Broad-Spectrum Kinase Inhibitor Bosutinib Leads to Potent and Selective Quinoline-Based HIPK4 Inhibitor AZ137.

by Athina Zerva, Nicolai D Raig, Zaile Zhuang, Andreas Krämer, Johannes Dopfer, Riley K Togashi, Martin Peter Schwalm, Lewis Elson, Julia M Frischkorn, Benedict-Tilman Berger, Susanne Müller, James K Chen, Stefan Knapp, Thomas Hanke — Journal of medicinal chemistry. Volume 69(17): 20616-20638. Sep 10, 2026.
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Created 10 Sep 2026

Design and Synthesis of Anemoside B4 Derivatives as Pyruvate Carboxylase-Targeting Therapeutic Agents for Atopic Dermatitis.

by Heng Li, Yexin Du, Qiurong Li, Junlei Zhang, Jianping Zhao, Mengxin Niu, Shuying Su, Aocheng Xie, Wei He, Guiyan Huang, Lihua Xiao, Zhichao Huang, Ikhlas A Khan, Shilin Yang, Suxiang Feng, Bin Huang, Qiongming Xu, Yanli Liu — Journal of medicinal chemistry. Volume 69(17): 20248-20280. Sep 10, 2026.
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Created 10 Sep 2026

Efficient Screening of High Bacterial Cell-Selective Antimicrobial Peptides via Proline Regulation Combined with a Universal Secondary Structure Template.

by Pengyi Yan, Lanqing Hu, Bingqian Ren, Xueting Liu, Zufang Ba, Jie Liu, Zhongwei Yu, Qingyang Xu, Liru Yuan, Jieyu Lu, Yumeng Li, Xia Tang, Jiayu Sun, Chao Zhong, Yun Zhang, Hui Liu, Sanhu Gou, Jingman Ni — Journal of medicinal chemistry. Volume 69(17): 20804-20826. Sep 10, 2026.
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Created 10 Sep 2026

Small-Molecule Activators of PRMT1: Discovery, SAR Analyses, and Proapoptotic Effects in Pancreatic Cancer Cells.

by Sepideh Salehipour-Bavarsad, Christian Iking, Jonas Kammertöns, Caroline Bouchard, Marion Meixner, Michael Daude, Wieland Steinchen, Felix Terwesten, Johanna Senst, David Vonhören, Sinja Rakow, Anne Kagerhuber, Sona Martirosian, Katrin Roth, Daniel Hilger, Stefanie Dörr, Gina Bach, Van Tuan Trinh, Anett Hauser, Frank Abendroth, Olalla Vázquez, Gert Bange, Jörg Walter Bartsch, Detlef Klaus Bartsch, Peter Kolb, Wibke E Diederich, Uta-Maria Bauer — Journal of medicinal chemistry. Volume 69(17): 20116-20137. Sep 10, 2026.
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Created 10 Sep 2026

Discovery and Crystallographic Study of Water-Soluble Quaternary Ammonium-Based PD-1/PD-L1 Inhibitors with Anti-Angiogenic Activity.

by Jianwei Xu, Pan Yang, Xixiang Yang, Yaoyao Shu, Lirong Zhang, Jiayi Zhou, Ling Li, Yichang Ren, Zichao Yang, Yibei Xiao, Jianjun Chen — Journal of medicinal chemistry. Volume 69(17): 20570-20595. Sep 10, 2026.
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