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Created 24 Sep 2026

Persistent TOP1 cleavage complexes in drug-tolerant cells drive adaptive resistance to EGFR-targeted therapies in lung cancer.

by Mathéa Geraud, Remi Gence, Anne Casanova, Estelle Taranchon-Clermont, Simona Salimbeni, Nesibe Özsu, Maina Vienne, Célia Delahaye, Elodie Borrull, Amélie Lusque, Mathilde Morisseau, Thomas Filleron, Delphine Pagan, Camille Taha, Agnese Cristini, Julien Mazières, Olivier Calvayrac, Gilles Favre, Anne Pradines, Olivier Sordet — Science advances. Volume 12(39): eaeh9099. Sep 25, 2026.
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Created 24 Sep 2026

Coordinated neural progenitor adaptations contribute to primate neocortical downscaling.

by Lidiia Tynianskaia, Cesar Mateo Bastidas-Betancourt, Esther Marie Grewe, Julia Marie Kniep, Neringa Liutikaite, Nesil Esiyok, İrfan Burak Göloğlu, Sabrina Heide, Nancy Rüger, Dimitri Lindenwald, Charis Drummer, Stoyan Petkov, Nataliya Di Donato, Michael Heide — Science advances. Volume 12(39): eaeg5563. Sep 25, 2026.
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Created 24 Sep 2026

A pontomesencephalic-mesolimbic circuit modulates activity-based anorexia.

by Beibei Peng, Xu Gao, Yan Chen, Yushi Xin, Yuxiao Zhang, Kexin Yu, Mingli Lu, Wenyan Li, Deqi Yang, Chaofei Bao, Shuai Liu — Science advances. Volume 12(39): eaee1476. Sep 25, 2026.
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Created 24 Sep 2026

Ultrasound-enhanced exosome secretion and antibody-free SERS profiling for Alzheimer's disease via iPSC-derived cortical organoids.

by Jinhee Yoo, Youngjun Kim, Won Jong Yu, Seongmin Kim, Yongjae Jo, Hanjun Cho, Hyunsu Park, Luke P Lee, Jong-Chan Park, Inki Kim, Byullee Park — Science advances. Volume 12(39): eaed3930. Sep 25, 2026.
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Created 24 Sep 2026

RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.

by Pushpamali De Silva, Samantha Fitzgerald, Jules Cazaubiel, Kristin Qian, Matan Hofree, Jia-Ren Lin, Roxanne Pelletier, Mariana Lopez Leon, Phuong Vu Mai Ho, Yasutoshi Takashima, Juha P Väyrynen, Kosuke Matsuda, Tomotaka Ugai, Dane Ford-Roshon, Pratyusha Bala, Nir Hacohen, Kimmie Ng, Jonathan A Nowak, Shuji Ogino, Peter K Sorger, Marios Giannakis — Science advances. Volume 12(39): eadz6907. Sep 25, 2026.
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Created 24 Sep 2026

Photoinitiator-free gelatin hydrogel microneedles for acute gouty arthritis treatment.

by Jianhua Zhang, Hengjie Zhang, Tianyou Wang, Wenjing Liu, Bao Xia, Liping Huang, Haoxing Wu, Yiwen Li, Zhipeng Gu — Science advances. Volume 12(39): eaei6340. Sep 25, 2026.
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Created 24 Sep 2026

Transmembrane delivery of antimicrobial peptides by engineered eCIS into macrophages for intracellular mycobacteria elimination.

by Qiqi Wu, Ruiwen Zhang, Mei-Yi Yan, Yu Wang, Xiao Feng, Wen Yang, Xin-Yuan Ding, Yi-Cheng Sun, Lingjun Zhan, Qi Jin, Feng Jiang — Science advances. Volume 12(39): eaee8463. Sep 25, 2026.
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Created 24 Sep 2026

Computational design of optimized and preferentially paired human TCR constant regions for improved T cell function.

by Maria Radman, Astar Shamul-Raybi, Jake Parker, Sarel J Fleishman, Cyrille J Cohen — Science advances. Volume 12(39): eaeb9189. Sep 25, 2026.
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Created 24 Sep 2026

Thalamofrontal synaptic weakening underlies short-term memory deficits from adolescent NMDAR hypofunction.

by Jinseon Yu, In Sun Choi, Gyu Hyun Kim, Sangkyu Bahn, Jinmo Kim, Sungwon Bae, Taekwan Lee, Joon Ho Choi, Jun Soo Kwon, Minah Kim, Ji-Woong Choi, Kea Joo Lee, Jong-Cheol Rah — Science advances. Volume 12(39): eaee2152. Sep 25, 2026.
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Created 24 Sep 2026

Mechanism of GPR84 allosteric modulation at a helix 8-proximate site.

by Xuan Zhang, Abdul-Akim Guseinov, Laura Jenkins, Jingkai Zhou, Fabian Gossen, Pinqi Wang, Zobaer Al Mahmud, Yueming Li, Andhika B Mahardhika, Christa E Müller, Mingye Feng, Angela J Russell, Irina G Tikhonova, Graeme Milligan, Cheng Zhang — Science advances. Volume 12(39): eaeh5849. Sep 25, 2026.
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