Latest Research Publications - Life Science Network

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Created 21 Sep 2026

Photothermal-driven sequential immunotherapy overcomes resistance to PARP inhibition in Brca1-deficient triple-negative breast cancer.

by Zhenyu Xu, Shengyi Wang, Yiyang Cao, Jianing Song, Yinghuan Liu, Rong Zhang, Xulin Tang, Ya Wang, Haodi Wu, Jiasheng Tu, Qian Chen, Chunmeng Sun — Acta pharmaceutica Sinica. B. Volume 16(9): 6235-6252. Epub Jul 17, 2026.
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Created 21 Sep 2026

APRIL-driven BCMA/TACI dual-targeted ligand-drug conjugates for selective and potent therapy of multiple myeloma.

by Linling Zhou, Yanping Sun, Jie Bi, Jiaqi Zhao, Yinli Xia, Jun He, Jisheng Wang, Liqiang Pan — Acta pharmaceutica Sinica. B. Volume 16(9): 5540-5552. Epub Feb 06, 2026.
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Created 21 Sep 2026

Single-cell transcriptomic atlas of the human fetal uveal tract reveals heterogeneity in melanocyte populations.

by James Draper, Ian R Reekie, Lakshanie Wickramasinghe, Srilakshmi Sharma, Mark Coles, Andrew D Dick, Christopher Buckley, Helen Kalirai, Sarah E Coupland — iScience. Volume 29(10): 117510. Oct 16, 2026.
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Created 21 Sep 2026

Single-Nucleus Transcriptomic Mapping Reveals Correlative Microglial Changes Associated with rTMS in the Motor Cortex After Spinal Cord Injury.

by Kunlong Zhang, Xinjiang Yang, Ruibin Hou, Rui Zhao, Dongjin Li, Hancheng Liao, Fei Tian, Xiaolong Sun, Hua Yuan — Journal of inflammation research. Volume 19: 633117. Epub Sep 16, 2026.
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Created 21 Sep 2026

Metrnl in mitigating radiation enteritis via label-retaining cells protection by modulating the c-KIT-WNT pathway.

by Sailong Zhang, Simin Chen, Bingjie Guo, Qisheng Ling, Shuling Wang, Zhuwei Miao, Zhi Wang, Yuchen Wei, Sili Zheng, Zhiyong Li, An-Qiang Feng, Feng-Hua Qian, Chao-Yu Miao — Acta pharmaceutica Sinica. B. Volume 16(9): 6129-6144. Epub Jun 18, 2026.
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Created 21 Sep 2026

Hepatokine FGL1 drives endothelial injury and atherogenesis via integrin β1-mediated endothelial-mesenchymal transition.

by Yixiu Zhao, Huan Chen, Liuqing Yin, Ruirui Meng, Jiangfei Zheng, Yue Zhang, Zhiqi Wang, Yi Chen, Rui Xu, Jing Liu, Yanxi Li, Na An, Houwei Li, Yan Zhang — Acta pharmaceutica Sinica. B. Volume 16(9): 5901-5925. Epub Jun 08, 2026.
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Created 21 Sep 2026

The ADP-ribosyltransferases 3 (ART3) is a novel suppressor of pathological cardiac hypertrophy by ribosylating ITGA7.

by Yilei Meng, Sangyu Hu, Fang Lin, Yuping Zhu, Yingying Xiong, Yizhuo Sun, Qin Lin, Mingxing Lu, Na Yi, Tao Xiao, Hanrui Wang, Jie Sheng, Ye Xu, Chenyu Li, Cuimei Zhao, Haojie Lu, Agapios Sachinidis, Li Li, Luying Peng — Acta pharmaceutica Sinica. B. Volume 16(9): 5944-5960. Epub Jul 01, 2026.
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Created 21 Sep 2026

Transcriptomic trajectory of hepatocyte ballooning reveals a lipotoxic point of no return and initiates oncogenic regulatory rewiring in MASLD.

by Debopriyo Ganguly, Bandana Mondal, Subhas Das, Indrashish Dey, Ayan Mandal, Trinath Ghosh, Monalisha Deo, Misba Ahmed, Soma Banerjee, Ankita Chatterjee, Priyadarshi Basu — Biochemistry and biophysics reports. Volume 48: 102785. Epub Sep 12, 2026.
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Created 21 Sep 2026

Development and validation of a machine learning scoring system based on multi-dimensional metabolic signatures for invasive examination triage in intestinal diseases.

by Jintao He, Jiaorong Chen, Yong Zhang, Yingbo Rao, Mengning He, Mingli Zhu — Frontiers in genetics. Volume 17: 1905165. Epub Sep 07, 2026.
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Created 21 Sep 2026

Genetic vulnerability and dynamic mechanical stress synergistically drive sarcomere failure in human iPSC-derived cardiomyocytes.

by Chenyan Wang, Nhu Y Mai, Fred J Donelson, Susan Moradi Nasab, Huaiyu Shi, Huaxiao Yang, Patrick T Mather, Xinrui Wang, James H Henderson, Zhen Ma — Materials today. Bio. Volume 40: 103667. Epub Sep 11, 2026.
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Publications

Heads up!

Photothermal-driven sequential immunotherapy overcomes resistance to PARP inhibition in Brca1-deficient triple-negative breast cancer.

APRIL-driven BCMA/TACI dual-targeted ligand-drug conjugates for selective and potent therapy of multiple myeloma.

Single-cell transcriptomic atlas of the human fetal uveal tract reveals heterogeneity in melanocyte populations.

Single-Nucleus Transcriptomic Mapping Reveals Correlative Microglial Changes Associated with rTMS in the Motor Cortex After Spinal Cord Injury.

Metrnl in mitigating radiation enteritis via label-retaining cells protection by modulating the c-KIT-WNT pathway.

Hepatokine FGL1 drives endothelial injury and atherogenesis via integrin β1-mediated endothelial-mesenchymal transition.

The ADP-ribosyltransferases 3 (ART3) is a novel suppressor of pathological cardiac hypertrophy by ribosylating ITGA7.

Transcriptomic trajectory of hepatocyte ballooning reveals a lipotoxic point of no return and initiates oncogenic regulatory rewiring in MASLD.

Development and validation of a machine learning scoring system based on multi-dimensional metabolic signatures for invasive examination triage in intestinal diseases.

Genetic vulnerability and dynamic mechanical stress synergistically drive sarcomere failure in human iPSC-derived cardiomyocytes.