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Created 28 Sep 2026

SPRED2 Negatively Regulates CD8⁺ T Cell-Mediated Antitumor Immunity in Breast Cancer.

by Miao Tian, Teizo Yoshimura, Kun Zhao, Chunning Li, Tong Gao, Ziyi Wang, Masayoshi Fujisawa, Toshiaki Ohara, Akihiro Matsukawa — Advanced science (Weinheim, Baden-Wurttemberg, Germany). Pages e77909. Sep 27, 2026.
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Created 28 Sep 2026

In Situ Bioorthogonal Synthesis of PROTACs via Dual-Responsive Cleavage for Synergistic Photo-Immunotherapy.

by Shiqin Jian, Jiasha Wu, Fusheng Xu, Yan Zuo, Huaxing Shen, Rui Ji, Luyi Wang, Na Li, Yanting Sun, Yongsheng Yu, Yejiao Shi, Honggang Hu, Feng Xu, Dan Huang, Xiaochun Hu — Advanced science (Weinheim, Baden-Wurttemberg, Germany). Pages e77938. Sep 27, 2026.
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Created 28 Sep 2026

Single-Cell Transcriptomic Profiling Identifies B Cell-Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia.

by Dongmei Luo, Yanxia Zhan, Lili Ji, Pengcheng Xu, Pu Chen, Hao Pang, Yunan Ling, Fanli Hua, Xibing Zhuang, Hao Chen, Yunfeng Cheng — Advanced science (Weinheim, Baden-Wurttemberg, Germany). Pages e77980. Sep 27, 2026.
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Created 28 Sep 2026

Co-activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease.

by Rahmi Lee, Gayeon Kim, Ellison R Black, Seonil Kim — Advanced science (Weinheim, Baden-Wurttemberg, Germany). Pages e77858. Sep 27, 2026.
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Created 28 Sep 2026

Degrading GPX4 via Biomimetic Nanoparticle-Mediated In Situ Synthesis of Deep-Learning-Designed Binder-Degron Chimeras for Prostate Cancer Therapy.

by Si-Han Zhang, Ye An, Na Zeng, Mei-Cheng Liu, Jian-Xuan Sun, Xi Gong, Jin-Zhou Xu, Shao-Gang Wang, Qi-Dong Xia — Advanced science (Weinheim, Baden-Wurttemberg, Germany). Pages e77932. Sep 27, 2026.
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Created 28 Sep 2026

Disentangling Heterogeneous Molecular Networks for Multi-Omics-Driven Cancer Driver Discovery.

by Xinjing Gong, Ji Li, Mu Su, Peishen Yu, Te Ma, Ruiyang Zhai, Chenye Zhang, Mengyan Zhang, Yan Zhang — Advanced science (Weinheim, Baden-Wurttemberg, Germany). Pages e77970. Sep 27, 2026.
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Created 28 Sep 2026

Puerarin‑Loaded pH‑Responsive ZIF‑90 Nanoparticles Ameliorate Osteoporosis via Enhancing H3K18 Lactylation and Suppressing Aberrant Osteoclast Activation.

by Jiajia Lu, Yue Xi, Sheng Wang, Ye Chen, Jiajie Yang, Xiaojian Shi — Advanced science (Weinheim, Baden-Wurttemberg, Germany). Pages e77869. Sep 27, 2026.
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Created 28 Sep 2026

CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti-PD-1 Therapy.

by Ji Wang, Xinyu Tang, Zeju Li, Qi Qi, Chang Sun, Wen Sun, Weiya Zhang, Yue Yin, Ya Deng, Peiwen Ling, Yifan Xu, Guangshun Sun, Yi Ren, Hong Pan, Shui Wang, Wenbin Zhou — Advanced science (Weinheim, Baden-Wurttemberg, Germany). Pages e77976. Sep 27, 2026.
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Created 28 Sep 2026

A Multi-Targeting Chimeric Antigen Receptor-T Cell Platform to Overcome Antigen Heterogeneity in the Treatment of Non-Small Cell Lung Cancer.

by Lina Wang, Yanlei Zhang, Shuixiu Peng, Chenchen Hou, Huaqi Guo, Tianyu Zhou, Alex H Chang, Lifeng Yan, Weining Xiong — Advanced science (Weinheim, Baden-Wurttemberg, Germany). Pages e77992. Sep 27, 2026.
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Created 28 Sep 2026

Platycodon grandiflorus-Derived Nanovesicles Sensitize Gastric Cancer to T Cell Killing via Ferroptosis-Driven Membrane Mechanical Remodeling.

by Jian Wu, Ruijuan Zhang, Yixin Duan, Shuqi Huo, Xiang Zhang, Yibin Xing, Lingjing Ma, Tiran Jiang, Xingyu Chen, Qingmin Sun — Advanced science (Weinheim, Baden-Wurttemberg, Germany). Pages e77900. Sep 27, 2026.
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