Latest Research Publications - Life Science Network

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Created 11 Nov 2026

Molidustat targets a synthetic lethal vulnerability in APC-mutant colorectal cancer through GSTP1 and PHD2 co-inhibition.

by Chiara Asselborn, Agata N Makar, Jair G Marques Junior, Aslihan Bastem Akan, Athanasia Yiapanas, Carrie Jennings, Ana Perez-Lopez, Jimi Wills, Asier Unciti-Broceta, Kevin B Myant, Alex von Kriegsheim — eLife. Volume 15. Nov 10, 2026.
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Created 11 Nov 2026

A three-tier framework for interacting immune-tolerance defects in primary biliary cholangitis.

by Zihao Xu, Yifan Liu, Sheng Guo, Liangbin Cheng, Jun Xu — Autoimmunity. Volume 59(1): 2756158. Dec 31, 2026.
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Created 11 Nov 2026

Pharmacological inhibition of coronavirus replication via modulation of host lipid metabolism.

by Maria Soultsioti, Montserrat Bárcena, Martin Giera, Eric J Snijder — The Journal of general virology. Volume 107(11).
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Created 11 Nov 2026

Molecular imaging of the TGF-β activating integrin αvβ6 detects chronic lung allograft dysfunction.

by Marlene Cano, Chandra S Bathula, Fuyi Liao, Cristian Wieczorek Villas Boas, Yan Tao, Zhiyi Liu, Ricky Ebenezer, Victoria Davis, Allison Cannady, Dequan Zhou, Shunning Liang, Hanqiu Zhao, Derek E Byers, Alexander S Krupnick, Daniel Kreisel, Susan M Lin, Allen Duong, Tereza Martinu, Zhiyu Dai, Buck E Rogers, Andrew E Gelman — JCI insight. Nov 10, 2026.
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Created 11 Nov 2026

Poly-γ-Glutamic Acid-Modified Carbon Dots as an Enhanced Immune-Activating and Antigen-Delivering Nano-adjuvant for Improved Influenza Vaccine Efficacy.

by Jungho Kim, Chang-Hun Yeom, Jihyun Yang, Haryoung Poo — ACS applied materials & interfaces. Nov 10, 2026.
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Created 11 Nov 2026

Dsg2 truncation causes a severe intestinal epithelial barrier breakdown and alters microbiome and immune response.

by Daniela Kugelmann, Alexander García-Ponce, Nadja Thielemann, Mariya Y Radeva, Maresa Anders, Da Eun Kang, Christian Siadjeu, Natalie Burkard, Anja Ke Horn, Jessica Neubauer, Matthias Hiermaier, Desalegn T Egu, Christoph Schmitz, Oliver Kurzai, Katri S Vuopala, Outi Kuismin, Nicolas Schlegel, Jens Waschke — JCI insight. Nov 10, 2026.
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Created 11 Nov 2026

HIV-resistant CD19/HIV-targeted dual CAR T cells control HIV replication and B cell lymphoma concurrently in humanized mice.

by Nan Liu, David Nardo, Vipin Bhardwaj, Joshua Glover, Divanshu Shukla, James L Riley — The Journal of clinical investigation. Nov 10, 2026.
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Created 11 Nov 2026

ATRX loss predicts poor outcomes and sensitizes to TEAD inhibition in soft tissue sarcomas.

by Ryan A Denu, Anand K Singh, Yingda Jiang, Zhao Zheng, Davis R Ingram, Khalida M Wani, Rossana Lazcano, Madison P Ginn, Kumaren Anand, Bishal K Singh, Jackson C Ballard, Veena Kochat, Biji Chatterjee, William Padron, Sharon M Landers, Angela D Bhalla, Asha S Multani, Sharvari Dharmaiah, Prit Benny Malgulwar, Yiming Cai, Jun Yao, Heather Lin, Jason T Huse, Haoqiang Ying, Emily Z Keung, Wei-Lien Wang, Anthony P Conley, Shreyaskumar Patel, Neeta Somaiah, Ahsan S Farooqi, Alexander J Lazar, Elise F Nassif Haddad, Keila E Torres, Kunal Rai — The Journal of clinical investigation. Nov 10, 2026.
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Created 11 Nov 2026

Effects of calreticulin mutations on HLA class I expression in myeloproliferative neoplasms.

by Amanpreet Kaur, Grace Pagnucco, Fawziyah S Khatri, Harini Desikan, Malathi Kandarpa, Matthew Cusick, Moshe Talpaz, Malini Raghavan — JCI insight. Nov 10, 2026.
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Created 11 Nov 2026

Nanoplastics Mitigate 6PPD-Induced Zebrafish Cardiac Ferroptosis Mediated by the GRK5/p53/SLC7A11 Pathway.

by Yilin Huang, Huan Ru, Chanlin Fang, Shanshan Di, You Weng, Mingrong Qian, Yuanxiang Jin — ACS nano. Volume 20(44): 29720-29732. Nov 10, 2026.
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