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Created 11 Jul 2026

Discovery of Potential First-in-Class Dual Ligand-Directed Degrader and Antagonist of the Androgen Receptor: BMS-986365.

by Deborah S Mortensen, Surendra Nayak, Veronique Plantevin-Krenitsky, Evan J Horn, Joseph Meiring, Samantha Reiss, Kimberly Peacock, Jingjing Zhao, Xiaochu Ba, Stephen Norris, Matt Alexander, Matthew Correa, Dehua Huang, Jean-Francois Brazeau, John Sapienza, Lida Tehrani, Mark Nagy, Brandon Whitefield, Patrick Papa, Roy Harris, Virginia Grant, John D Norris, Massimo Ammirante, Emily Rychak, Suzanne E Wardell, Toshiya Tsuji, Courtney G Havens, Ken Liu, Joseph R Piccotti, Deepak Dalvie, Yang Tang, Nadia Guerrero, Lisa Sapinoso, Joshua Baughman, Brian E Cathers, Mark Rolfe, Lawrence G Hamann, Donald P McDonnell, Rama Krishna Narla, Joshua D Hansen, Shuichan Xu — Journal of medicinal chemistry. Jul 10, 2026.
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Created 11 Jul 2026

AI-guided identification of natural CTSL inhibitors with therapeutic potential for renal injury.

by Feier Ma, Qi Li, Sirui Zhou, Xiaoya Li, Jin-Kui Yang — PLoS computational biology. Volume 22(7): e1014464. Jul 10, 2026.
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Created 11 Jul 2026

Sp1 links CD46 to CD4 T cell metabolic fitness, survival, and retroviral control.

by Parul Singh, Luopin Wang, Pavitra Ramdas, Shyaman M Jayasundara, Gaelle Le Friec, Natalia Kunz, Prakriti Mudvari, Erin E West, Ayden Case, Nicolas S Merle, Jack A Bibby, Henrik Hasle, Eli A Boritz, Majid Kazemian, Claudia Kemper — Science immunology. Volume 11(121): eaeb5857. Jul 10, 2026.
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Created 11 Jul 2026

The efficacy of immunotherapy in glioma requires distal B cell responses in tumor-draining lymph nodes.

by Yumin Kim, In Kang, Byeong Hoon Kang, Won Hyung Park, Chae Won Kim, Hyun-Jin Kim, Jeongwoo La, Myoung Seung Kwon, Sang Hee Park, Seo Hyeon Im, Hyeon Cheol Kim, Keun Bon Ku, Minji Kim, Ji Eun Oh, Heung Kyu Lee — Science immunology. Volume 11(121): eadz2494. Jul 10, 2026.
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Created 11 Jul 2026

A Dsg3-specific pemphigus autoantibody induces formation of immature desmosomes associated with impaired adhesion.

by Julia Huber, Michael Fuchs, Jens Waschke, Christoph Hudemann, Lukas F Reissig, Thomas Schmitt — Tissue barriers. Pages 2700483. Jul 10, 2026.
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Created 11 Jul 2026

Infection of Rhesus Macaques with O'nyong-nyong virus UVRI-0804 recapitulates key aspects of human clinical disease.

by Hannah K Jaeger, Michael Denton, Takeshi F Andoh, Craig N Kreklywich, Lina Gao, Lydia J Pung, Zachary J Streblow, Ann McMonigal, Karina Ray, Brayden Graves, Magdalene M Streblow, Aaron M Barber-Axthelm, Gavin Zilverberg, Margaret Terry, Suzanne S Fei, Glenn Hogan, David C Schultz, Sara Cherry, Michael K Axthelm, Caralyn S Labriola, Mark T Heise, Daniel N Streblow — PLoS neglected tropical diseases. Volume 20(7): e0013780. Jul 10, 2026.
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Created 11 Jul 2026

Sex differences in the regulation and function of cellular immunity in Drosophila.

by Alexandra Dvoskin, Kevin Y L Ho, Michael Allara, Nicola Janz, Elizabeth Rideout, Juliet R Girard, Guy Tanentzapf — PLoS genetics. Volume 22(7): e1012151. Jul 10, 2026.
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Created 11 Jul 2026

H2BE113K mutation promotes breast cancer metastasis through modulating chromatin dynamics.

by Shiman Hu 胡诗曼, Jiaxian Liu, Jiaqi Zhou, Jiaohua Chen, Tiantian Qin, Yi Ching Esther Wan, Xiaoxuan Zhu, Danyi Wang, Chuting Shao, Yabin Chen, Xin Wang, Junhong Han, Hoi Leong Xavier Wong, Robert S Weiss, Haojie Jin, Mo Chen, Qing Li, Yogen Saunthararajah, Haiyun Gan, Kui Ming Chan 陈居明 — Science advances. Volume 12(28): eadx4982. Jul 10, 2026.
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Created 11 Jul 2026

Periodic shifts in viral load increase risk of Hendra virus spillover from Pteropus bats.

by Tamika J Lunn, Benny Borremans, Devin N Jones-Slobodian, Maureen K Kessler, Adrienne S Dale, Claude K Yinda, Manuel Ruiz-Aravena, Caylee A Falvo, Daniel E Crowley, James O Lloyd-Smith, Vincent J Munster, Peggy Eby, Hamish McCallum, Peter Hudson, Olivier Restif, Liam P McGuire, Ina L Smith, Bat One Health Group Collaborators, Raina K Plowright, Alison J Peel — Science advances. Volume 12(28): eaea6654. Jul 10, 2026.
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Created 11 Jul 2026

Congenital blindness reduces myelination in human visual cortex.

by Anna-Lena Stroh, Luke J Edwards, Daniel Haenelt, Fakhereh Movahedian Attar, Kerrin J Pine, Robert Trampel, Marcin Szwed, Nikolaus Weiskopf — Science advances. Volume 12(28): eaec2348. Jul 10, 2026.
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