Brain aging shows nonlinear transitions, suggesting a midlife “critical window” for metabolic intervention

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Proceedings of the National Academy of Sciences, National Academy of Sciences

Content

Proceedings of the National Academy of Sciences, Volume 122, Issue 10, March 2025.

SignificanceAge-related cognitive decline is associated with metabolic, vascular, and inflammatory changes, making it challenging to distinguish primary causes from secondary (downstream) effects. This study demonstrates that brain aging follows a ...

Botond B. AntalHelena van NieuwenhuizenAnthony G. ChesebroHelmut H. StreyDavid T. JonesKieran ClarkeCorey WeistuchEva-Maria RataiKen A. DillLilianne R. Mujica-ParodiaDepartment of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NYbLaufer Center for Physical and Quantitative Biology, State University of New York at Stony Brook, Stony Brook, NYcAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MAdDepartment of Physics, State University of New York at Stony Brook, Stony Brook, NYeDepartment of Neurology, Mayo Clinic, Rochester, MNfDepartment of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United KingdomgDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NYhSanta Fe Institute, Santa Fe, NM

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