Quantifying direct genetic signal captured by principal component adjustment

Published in

Proceedings of the National Academy of Sciences, National Academy of Sciences

Content

Proceedings of the National Academy of Sciences, Volume 123, Issue 18, May 2026.

SignificanceGenomic studies of complex traits often include genetic principal components (PCs) among their adjustments for population stratification. However, alleles with direct genetic effects may also display systematic differences across major axes of ...

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