Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration

Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration | Science

Journal content Created on 07 May 2026 Science

Published in

Science, American Association for the Advancement of Science

Content

Aberrant aggregation of the prion-like RNA binding protein TDP-43 drives several fatal neurodegenerative proteinopathies, including amyotrophic lateral sclerosis (ALS). In this work, we define how short, specific RNAs solubilize TDP-43. These short RNAs ...

Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration | Science

Attention!

On Life Science Network, we import abstract of articles published in the most popular journals. In addition, members of our network often upload full article pdfs of their research.

To access all content shared in our network and the source link, please sign up for an account. If you already have an account, sign in, or connect with LinkedIn, Google.

Stats

Recommendations n/a n/a positive of 0 vote(s)
Views 46
Comments 0

Comments

There are no comments yet.