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How to benchmark medical AI agents

Journal content Created on 09 Jul 2026 PLOS Medicine

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PLOS Medicine, Public Library of Science

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by Silas Ruhrberg Estévez, Dyke Ferber, Mihaela van der Schaar, Jakob Nikolas Kather

Medical artificial intelligence research is shifting from single-task models toward multimodal large language model-based agents for complex clinical workflows, requiring benchmarks that assess clinical reasoning, process safety, and resource stewardship rather than final outputs alone. In this Perspective article, Silas Ruhrberg Estévez and colleagues discuss why, as medical AI research shifts toward multimodal large language model-based agents for complex clinical workflows, benchmarks that assess clinical reasoning, process safety, and resource stewardship—rather than final outputs alone—are required.

Jakob Nikolas Kather

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