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Progress and promise of CAR-T cell treatment in autoimmune diseases

Journal content Created on 20 Jul 2026 PLOS Medicine

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PLOS Medicine, Public Library of Science

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by Jule Bachl, Melanie Hagen, Georg Schett

Chimeric antigen receptor (CAR)-expressing cells bear a great potential for the treatment of autoimmune diseases. While numerous challenges persist, recent technological developments have demonstrated the potential for CAR cells to reset dysfunctional immune systems and transform care for patients with autoimmune disease. Chimeric antigen receptor (CAR)-expressing cells bear a great potential for the treatment of autoimmune diseases. In this Perspective, Jule Bachl, Melanie Hagen, and George Schett discuss the challenges and potential of recent technological developments for transforming care for patients with autoimmune disease.

Georg Schett

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