Maternal congenital heart disease: Implications for the next generation

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PLOS Medicine, Public Library of Science

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by Elisabeth Leirgul, Gottfried Greve

Advances in medical and surgical treatment of congenital heart disease (CHD) now allows most affected individuals to reach adulthood and parenthood. While maternal CHD is associated with pregnancy complications, emerging evidence suggests a possible increased risk of developmental challenges in offspring, particularly among children of mothers with severe CHD. In this Perspective, Elisabeth Leirgul and Gottfried Greve discuss emerging evidence that as well as maternal congenital heart disease (CHD) being associated with pregnancy complications, there is also a possible increased risk of long-term developmental challenges in offspring, particularly among children of mothers with severe CHD.

Gottfried Greve

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