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Expanding the Developmental Origins of Health and Disease beyond maternal behaviors

Journal content Created on 30 Jul 2026 PLOS Medicine

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PLOS Medicine, Public Library of Science

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by Alice Rhiannon Lee, Daniel B. Hawcutt, Jennifer K. Quint, Ian P. Sinha

Developmental Origins of Health and Disease (DOHaD) research has long emphasized maternal pregnancy behaviors as key determinants of child health. New evidence recently published in PLOS Medicine suggests the greatest opportunities to improve child health may lie in tackling socioeconomic disadvantage rather than maternal behavior alone. Developmental Origins of Health and Disease (DOHaD) research has long emphasized maternal pregnancy behaviors as key determinants of child health. In this Perspective, Alice Rhiannon Lee and colleagues discuss new evidence that suggests the greatest opportunities to improve child health may lie in tackling socioeconomic disadvantage rather than maternal behavior alone.

Ian P. Sinha

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