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Addressing threats to validity in large dataset research

Journal content Created on 02 Nov 2026 PLOS Medicine

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PLOS Medicine, Public Library of Science

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by Wonsuk Yoo, John P. A. Ioannidis

In this Guidelines and Guidance article, Wonsuk Yoo and John P.A. Ioannidis outline why research using large datasets faces threats to validity, highlighting four main statistical pitfalls and providing guidance and worked examples on how to mitigate against them.

John P. A. Ioannidis

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