Speaker
Ian Scanlon, Dr. Christie Childers
When and where
Starts: Thursday, 20 February 2025 - 09:30
Ends: Thursday, 20 February 2025 - 10:30
Location:
Xtalks, Toronto, Canada
Location details: Free Registration on Xtalks.com
Event description
Discover an informative webinar to learn how target-specific adsorbents enable increase in productivity due to increased manufacturing speed and recovery yield while achieving the purity levels for the product quality attributes required by regulatory authorities.
A novel purification approach is required to address the complex purification challenges of critical raw materials for cell and gene therapies (CGT) such as plasmid DNA (pDNA) and lentiviral vectors (LVV). The purification technology needs to be optimized for large and fragile CGT modalities, allowing downstream processing under low operational pressure and low salt buffers.
In this webinar, the expert speakers will share data and insights on the development of a low salt, high recovery yield and lentiviral vector purification workflow, with efficient removal of impurities such as host cell proteins and dsDNA. Attendees will also learn how the performance of the anion exchange adsorbent compares to alternative commercially available chromatography options. The expert speakers will also discuss a scalable downstream workflow for efficient pDNA manufacturing at full-speed operation while maintaining low column pressure.
Attendees will also learn how processing of highly viscous feeds such as large pDNA sequences (e.g., greater than 10 kb) required in CGT can be considerably simplified. The speaker will also demonstrate how the hydrophobic adsorbent integrated into the flexible workflow can be used as a capture step or a polish step to adapt to the varying and growing process needs.
Register for this webinar today to gain insights into increasing the downstream processing and purification of cell and gene therapeutics.
Further details
IMPORTANT: In order to register to this free webinar you must register directly on Xtalks via the following URL: https://xtalks.com/webinars/success-stories-for-challenging-pdna-and-viral-vectors-downstream-processing/
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