PhD Project "Dissecting innate immune cell reactivity against hepatitis B/D viral infection" (TRR179_Immunity to Hepatitis virus) - Heidelberg University

Employer

Dept. of Immunbiochemistry, University Hospital Mannheim, Mannheim, Germany

Description

Our department focuses on (innate) immune cells and their exploitation in the immunotherapy for cancer and viral infection. Co-infection with hepatitis B and hepatitis D virus (HBV/HDV) can cause the most severe form of viral hepatitis. Current knowledge about the function of the immune system, especially virus-reactive innate(-like) immune cells including natural killer (NK) and gd T cells in this infection is limited. We established a robust co-culture model that allows for the study of human immune cell reactivity to HDV infection in vitro and demonstrated a profound interferon-beta-mediated activation and cytotoxicity of human NK cells (1). To follow up on these findings we are looking for a PhD student to investigate: i) The response of NK cells and gd T cells to HDV/HBV co-infection, ii) Modulation of NK and gd T cell activity by macrophages/monocytes and plasmacytoid dendritic cells
For more information please visit
https://www.trr179.de/en/
https://www.umm.uni-heidelberg.de/immunbiochemie/
for more information please contact:
Dr. Christopher Groth
[email protected]
Prof. Dr. Adelheid Cerwenka;
[email protected]

Candidate requirements

Profile of candidate’s qualification: We are looking for a candidate passionate about scientific research and the ability to develop and pursue independent ideas. The successful candidate must hold a university degree in Biology, Biomedicine or related fields (master or equivalent) and must demonstrate excellent English language skills. Further prerequisites include a profound knowledge of cell and molecular biology and immunology.

Further details

Possible start of employment: Friday, 01 November 2024.

Contract: Full-time, Fixed-term

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