PostDoc (m/f/d) – Comparative Genomics

Employer

TBG, Senckenberg Gesellschaft für Naturforschung, Frankfurt, Germany

Description

The Hiller Lab at the LOEWE-TBG in Frankfurt is looking for an ambitious

PostDoc (m/f/d) – Comparative Genomics

The mission of our group is to discover genomic determinants of phenotypic differences between species, which is important to understand how nature's fascinating phenotypic diversity evolved and how it is encoded in the genome. Work in the lab ranges from genome assembly and alignment to annotating genes, developing and applying comparative genomic methods to discover key differences in genes (such as loss, gain, selection) and regulatory elements, and using statistical approaches to associate genomic to phenotypic differences [1-8].

The postdoc will join our efforts to extend our methods repertoire to accurately detect additional types of genomic changes, to adopt them to other taxonomic groups, and to apply them on a large-scale to existing and numerous newly-sequenced genomes generated by us and our TBG collaborators.

Recent publications

[1] Jebb et al. Six reference-quality genomes reveal evolution of bat adaptations. Nature, 583, 578–584, 2020

[2] Huelsmann et al. Genes lost during the transition from land to water in cetaceans highlight genomic changes associated with aquatic adaptations. Science Adv, 5(9), eaaw6671, 2019

[3] Hecker et al. Convergent gene losses illuminate metabolic and physiological changes in herbivores and carnivores. PNAS, 116(8), 3036-3041, 2019

[4] Roscito et al. Phenotype loss is associated with widespread divergence of the gene regulatory landscape in evolution. Nature Communications, 9:4737, 2018

[5] Langer et al. REforge associates transcription factor binding site divergence in regulatory elements with phenotypic differences between species. MBE, 35(12), 3027–3040, 2018

[6] Lee et al. Molecular parallelism in fast-twitch muscle proteins in echolocating mammals. Science Adv, 4(9), eaat9660, 2018

[7] Sharma et al. A genomics approach reveals insights into the importance of gene losses for mammalian adaptations. Nature Communications, 9(1), 1215, 2018

[8] Nowoshilow et al. The axolotl genome and the evolution of key tissue formation regulators. Nature, 554(7690), 50-55, 2018

Candidate requirements

·         PhD degree in bioinformatics / computational biology, genomics or a related area

·         a strong publication record

·         excellent programming skills in a Linux environment as well as experience with shell scripting and Unix tools

·         previous experience in large-scale comparative genomic data analysis is an advantage.

About the employer

The Senckenberg Gesellschaft für Naturforschung (SGN) is a member of the Leibniz Association and is based in Frankfurt am Main, Germany. LOEWE Centre for Translational Biodiversity Genomics (LOEWE-TBG) is a joint venture of the Senckenberg Gesellschaft für Naturforschung (SGN), Goethe-University Frankfurt, Justus-Liebig-University Giessen and Fraunhofer Institute for Molecular Biology and Applied Ecology IME aiming to intensify biodiversity genomics in basic and applied research. We will establish a new and taxonomically broad genome collection to study genomic and functional diversity across the tree of life and make genomic resources accessible for societal-demand driven applied research.

Further details

Salary and benefits are according to a full time public service position in Germany (TV-H E 13, 100%). The contract should start as soon as possible and will be initially for 2 years, but funding is available to extend it further. The Senckenberg Gesellschaft für Naturforschung supports equal opportunity of men and women and therefore strongly invites women to apply. Equally qualified handicapped applicants will be given preference.

Possible start of employment: Friday, 01 January 2021.

Contract: Full-time, Fixed-term

Salary: TV-H E13

How to apply

Please send your application before October 25th, 2020 as a single pdf file via email to [email protected], mentioning the reference of this job offer (ref. #12-20021). The attached single pdf file should include the CV with publication list, contact information for at least two references, and a summary of your previous research experience (max 1 page).

Application email: [email protected]

Application deadline: Sunday, 25 October 2020 (in 0 minutes).

Source: https://www.senckenberg.de/de/ueber-uns/karriere/wissenschaftler/

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