Review of current state in α-helix-mediated protein–protein interactions field and discovery of protein-protein interaction inhibiting molecules.
Protein-protein interactions are important for virtually all cellular processes. Compromised protein-protein interactions can contribute to diseases, which makes identification of protein-protein interaction inhibitors highly desirable in drug discovery. In the latest issue of Nature Chemistry, Azzarito et al. review α-helix-mediated PPIs and current status in protein-protein interaction inhibitor development field.
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Cover image: PPI scheme.
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