Authors
Sun, L., Wabitsch, M., Yang, J., Sakharkar, M.
Abstract
Adipogenesis involves adipocyte differentiation and synthesis and storage of fats. PPAR-{gamma} is the master regulator of adipogenesis and regulates genes for adipocyte differentiation, lipogenesis, adipocyte survival and adipokine secretion. Central carbon metabolism (CCM) comprises of three key pathways, glycolysis, tricarboxylic acid cycle and pentose phosphate pathway. CCM utilizes carbon sources to provide energy and building blocks for lipogenesis. Although several targets of PPAR-gamma have been identified in the CCM pathways, the exact process of how PPAR-gamma modulates adipogenesis via CCM remains elusive. In this study, we used real time-qPCR and metabolic arrays for CCM to understand the effect of PPAR activation by PPAR-gamma agonist 15d-PGJ2 on CCM and its role in adipogenesis. Our data show that PPAR-delta is likely the target of 15d-PGJ2 and the key modulator of adipogenesis in human SGBS adipocytes at least under current experimental conditions. Further studies are warranted to fully understand the regulation of CCM in adipocytes.
Preprint server:
bioRxiv
The authors list and abstract were imported from bioRxiv on 11 Nov 2025.
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