Authors
Saul, M. C., Bratcher-Petersen, N., Ruidiaz, M. E., Oberhauser, J. P., Philip, V. M., Bolin, S. E., Gaskill, B. N., Robertson, T. L.
Abstract
Reproducibility is a persistent challenge in preclinical research. We used multi-week rodent digital home cage monitoring at three different pharmaceutical companies to examine factors governing replication of genetic differences in activity. Interlaboratory replication of genotype effects was surprisingly high. Longer study durations reduced noise, improving replication and reducing replicable sample sizes. These findings demonstrate the potential of long-term home cage digital monitoring as a method to enhance reproducibility.
Preprint server:
bioRxiv
The authors list and abstract were imported from bioRxiv on 31 Oct 2025.
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