Aptamer-based DNA nanoswitches for multiplexed protein detection

Authors

Kovvali, S., Beckles, C. A., Chandrasekaran, A. R., Halvorsen, K.

Abstract

Simple, modular platforms for detecting biologically relevant proteins are critical for applications in clinical diagnostics, healthcare, and research. Here, we have combined aptamer-based protein recognition with our conformationally-responsive DNA nanoswitches to enable simple, sensitive and specific protein detection. We demonstrate dual detection of two clinically relevant blood proteins, thrombin and VEGF as initial proof of concept.

Preprint server: bioRxiv
The authors list and abstract were imported from bioRxiv on 07 May 2026.

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