Authors
Huang, N., Wang, H. E., Triebkorn, P., Gandini Wheeler-Kingshott, C. A. M., Jedyank, M., David, O., Destexhe, A., D'Angelo, E. U., Pedersen, N. P., Jirsa, V.
Abstract
The human structural connectome, most commonly derived from diffusionweighted imaging (DWI) and tractography, provides a macroscopic description of whole-brain wiring and serves as the structural foundation of network neuroscience, large-scale brain simulations, and personalized digital brain twins. However, tractography-derived connectomes are fundamentally limited by their inability to distinguish afferent from efferent connections, yielding networks that are undirected and therefore blind to the hierarchical organization imposed by the directionality of anatomical connections. In this study, we introduce a directed human structural connectome (DHSC) by transferring tracer-derived projection patterns from macaque to human using cross-species connectivity blueprints. Topological analysis of the DHSC manifests biological plausibility, a small-world network organization, and a directionality-based hierarchy, which offer the hierarchical organization of human brain networks. In the context of brain dynamics, the introduction of directionality reshapes the propagation and persistence of sensory inputs. DHSC also best captures the empirical spatiotemporal dynamics of stimulus-evoked brain activity. The findings demonstrate that anatomical directionality is a critical determinant of large-scale brain organization and dynamics. This provides evidence that directed connectome may offer potential advantages in large-scale simulations of the human brain. The resulting DHSC, along with all related analyses and data are openly available.
Preprint server:
bioRxiv
The authors list and abstract were imported from bioRxiv on 18 Jun 2026.
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