Advances in the Design and Functionality of a Compact Multi-Reflecting Time-of-Flight Mass Spectrometer

Authors

Wildgoose, J., Ferries, S., Gethings, L. A., Daly, M. E., Palmer, M. E., Lock, R., Vissers, J. P., Langridge, J. I.

Abstract

High-resolution mass spectrometry is routinely used for the analysis of complex samples in pharmaceutical, environmental, and omics related studies. Such applications require instrumentation to be capable of combining sub-ppm mass accuracy, high resolving power, rapid full m/z range acquisition, and a wide dynamic range. Achieving these requirements simultaneously places constraints on analyzer design and performance. Multi-reflecting time-of-flight (MRT) based analyzers have been previously reported as a means of extending effective flight path length in compact TOF designs. Here, further instrument and functionality advances in a compact MRT mass spectrometer design are described and the impact of these enhancements is demonstrated for omics applications.

Preprint server: bioRxiv
The authors list and abstract were imported from bioRxiv on 20 Jun 2026.

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