Fructooligosaccharide Supplementation Improves Glucose Homeostasis in Human-Relevant hyperglycemic Diet-Induced Obese Mice

Authors

Saxena, U., Shahapur, S., Mehboob, S., Jadhav, P., Samal, T., Kadiyala, G., Gorantla, M.

Abstract

Fructooligosaccharides (FOS) are prebiotic fibers that influence gut microbiota and host metabolic function. In a diet-induced obesity (DIO) mouse study, FOS supplementation was compared with PBS-treated obese controls. Blood glucose was markedly lower at Day 42 (221.9 +/- 7.8 vs 138.3 +/- 9.0 mg/dL) and remained lower at Day 56. FOS reduced body weight gain from 8.4 +/- 0.9 g in PBS controls to 2.6 +/- 0.2 g, corresponding to an approximately 69.5% reduction in weight gain over Days 1-70. Cumulative feed consumption was not significantly different between PBS and FOS cages, suggesting that the observed metabolic effects were not simply explained by reduced food intake. These findings support the hypothesis that FOS functions as an active metabolic ingredient acting through the gut-liver-metabolic axis. In this study, dietary FOS supplementation produced marked improvements in glucose homeostasis in a severe DIO model characterized by diabetic-range hyperglycemia that more closely resembles poorly controlled human type 2 diabetes.

Preprint server: bioRxiv
The authors list and abstract were imported from bioRxiv on 30 Jun 2026.

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