N-Methyl-D-Aspartate receptors control in vivo striatal calcium and the updating of action policy

Authors

Legaria, A. A., Barrett, M. R., Czarny, J. E., Kravitz, A. V.

Abstract

Animals must execute learned behaviors and update them when outcomes change, yet the neural substrates controlling this phenomenon are not fully understood. Here, we show that N-Methyl-D-Aspartate Receptors (NMDARs) in the dorsomedial striatum are necessary for learning from previously rewarded actions. Moreover, blocking of striatal NMDARs almost fully abolished striatal calcium dynamics, but not action potential activity, suggesting a unique function of NMDAR-driven striatal calcium activity in updating action policy.

Preprint server: bioRxiv
The authors list and abstract were imported from bioRxiv on 11 Jul 2026.

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