An Approach to Measure Conductivity Gradients of Brain Tissue Transitions using Electrode Arrays

Authors

Symmank, M., Gerber, M., Knoesche, T., Gueresir, E., Wilhelmy, F., Weise, K.

Abstract

Accurate determination of surgical margins is critical in tumor resection to ensure complete removal of tumorinfiltrated tissue while preserving healthy tissue. Pathological assessment provides reliable information but is time-consuming. This study investigates the feasibility of using impedance spectroscopy to detect tissue transitions at a macroscopic level. Two electrode arrays - one-dimensional and two-dimensional - were applied to ex vivo porcine brain tissue. Measurements were performed using both two- and four-electrode configurations, and data were corrected using the multiple-load compensation method. Results demonstrate that the one-dimensional array provides continuous conductivity profiles corresponding to tissue transitions, while the two-dimensional array showed less consistent results. These findings suggest that impedance spectroscopy is a promising tool for intraoperative margin detection, but further optimization of electrode geometry and measurement data processing is required.

Preprint server: bioRxiv
The authors list and abstract were imported from bioRxiv on 17 Jul 2026.

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