A biofilm-derived peptide as an underwater adhesive

Authors

Huang, X., Liszczyk, E. D., Prasad, R., Mitchell, M. E., Wang, Z., Liu, Y., Saluja, S., Wang, M., Jackson, R. A., Dahl, P., Andresen Eguiluz, R. C., Malvankar, N., Yan, E. C. Y., Olson, R., Zhou, H.-X., Yan, J.

Abstract

Wet adhesives that perform under water have broad applications in industrial and biomedical settings. To date, molecular designs for underwater adhesives have largely been inspired by marine animals including mussels and barnacles. Here, we propose bacterial biofilms as an alternative source of inspiration for underwater adhesives. Specifically, we demonstrate the application potential of a peptide derived from biofilms formed by the notorious pathogen Vibrio cholerae. We characterize the ability of this biofilm-derived peptide to adsorb onto various surfaces and to glue wet surfaces, by using a combination of confocal microscopy, molecular dynamics simulations, atomic force microscopy, lap shear tests, and spectroscopic tools. We further show that the peptide can co-aggregate with microspheres acting as an effective flocculant. Finally, we succeeded in purifying this peptide from E. coli in a functional form, setting the stage for large-scale production. Our results open new design possibilities for underwater adhesives inspired by natural biofilms.

Preprint server: bioRxiv
The authors list and abstract were imported from bioRxiv on 07 Aug 2026.

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