Distinct mitochondrial phenotypes align with visual and semantic representations across human cortex

Authors

Lu, Z., Wang, Y.

Abstract

How cellular energetics relates to the information represented by human cortex is unknown. Using 7T fMRI during natural-scene viewing, image-to-brain encoding frameworks, spatial-autocorrelation-preserving inference and postmortem molecular atlases, we separated cortical variance uniquely attributable to visual versus semantic features. Visual-specific variance aligned negatively with mitochondrial density and respiratory capacity, whereas semantic-specific variance aligned positively with mitochondrial density; convergent transcriptomic enrichment linked these representational axes to opposing mitochondrial and cellular programs.

Preprint server: bioRxiv
The authors list and abstract were imported from bioRxiv on 09 Aug 2026.

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