Parabrachial oxytocin receptor-expressing neurons link social observation of distress to defensive behavior

Authors

Judd, E. N., Pauli, J. L., Kenmochi, S. J., Bruchas, M. R., Palmiter, R. D.

Abstract

The ability to detect and respond to threat signals in the environment, including those conveyed by the distress of a familiar social partner, is fundamental to survival and disrupted in a range of neuropsychiatric conditions. This study identifies oxytocin receptor (Oxtr)-expressing neurons within the lateral parabrachial nucleus (lPBN) of mice as a key node in the neural circuitry underlying threat-related and social behaviors. These Oxtr neurons are activated by aversive stimuli and by observing demonstrator mice in stressful situations, including foot shock or inflammatory pain. Chemogenetic inhibition of these neurons alters social proximity and pain contagion in observers without affecting general anxiety-like behavior. Inhibition also transiently suppresses non-social central sensitization. Direct activation of lPBNOxtr neurons with a selective Oxtr agonist is anxiogenic and results in increased tactile sensitivity. Together, these findings suggest that lPBNOxtr neurons are poised to integrate information about environmental threat, whether experienced directly or witnessed in a conspecific to coordinate appropriate defensive behavioral responses.

Preprint server: bioRxiv
The authors list and abstract were imported from bioRxiv on 09 Aug 2026.

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