Nanopore sequencing measures chromosome end-specific telomere lengths in human cells

Authors

Groot, A., Karimian, K., Rechsteiner, A., Greider, C. W.

Abstract

Telomere length has a significant impact on human health. Short telomeres cause age-related diseases, including pulmonary fibrosis, immunodeficiency, and bone marrow failure, while long telomeres predispose to cancer. Given the impact on human health, accurately measuring telomere length is important. A variety of methods have been developed over the past 40 years to measure telomere length. Many of these methods report only on the mean length of all of the telomere in the cell. Here, we describe the Telomere Profiling protocol using Oxford Nanopore Technologies (ONT) based on long read sequencing that can accurately measure chromosome specific telomere length.

Preprint server: bioRxiv
The authors list and abstract were imported from bioRxiv on 19 Aug 2026.

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