Radiological Patterns in Maxillofacial Ewing Sarcoma: A systematic review with pooled patient-level descriptive analysis

Authors

George, A. B., Maharana, S., Agarwal, R., George, A. M., Khurana, S.

Abstract

BackgroundEwing sarcoma (ES) is a rare malignant bone tumor with predilection for the mandible and maxilla in the head and neck region. However, existing literature comprises fragmented case reports and small case series that fail to establish consolidated, evidence-based understanding of characteristic radiological patterns in the maxillofacial region, hindering timely diagnosis and potentially leading to misdiagnosis or delayed intervention. MethodologyA systematic review and pooled patient-level descriptive analysis were conducted according to the PRISMA guidelines and pre-registered on PROSPERO. Comprehensive searches of PubMed, OVID, and Cochrane databases (inception to July 2025) identified studies reporting radiological findings of biopsy-confirmed maxillofacial Ewing sarcoma. Quality assessment using Joanna-Briggs Institute criteria ensured inclusion of only high-quality cases (quality score [≥]4/5). Synthesis Without Meta-analysis (SWiM) methodology with pooled prevalence estimation and binomial vote-counting analysis were employed for 68 published cases. ResultsFour radiological features demonstrated consistent predominance across pooled cases: soft tissue mass presence (100%, 95% CI: 94.7-100.0%), enhancing soft tissue (77.6%, 95% CI: 65.8-86.9%), cortical destruction (69.0%, 95% CI: 55.5-80.5%), and notably, absence of periosteal reaction (84.7%, 95% CI: 73.0-92.8%). Location-specific radiological phenotypes were evident: maxillary tumors demonstrated near-universal sinus involvement (100%) with high soft tissue enhancement (92.3%), whereas mandibular tumors showed predominant cortical destruction (80.0%) and teeth involvement (81.2%). ConclusionMRI and CT are essential for characterizing the distinctive radiological profile of maxillofacial Ewing sarcoma, enabling early identification and improving patient outcomes in this rare malignancy. HighlightsO_LIFirst pooled review to summarize imaging features of maxillofacial Ewing sarcoma C_LIO_LIAnalysis of 68 published cases reveals consistent imaging patterns. C_LIO_LIMost tumors show soft tissue mass and bone damage without surface reaction. C_LIO_LIJaw tumors differ from long bone tumors in their imaging appearance. C_LIO_LIUpper and lower jaw tumors show distinct location-specific features. C_LI

Preprint server: bioRxiv
The authors list and abstract were imported from bioRxiv on 23 Aug 2026.

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