Cerebellar influences on neocortical development in humans and mice

Authors

Gaiser, C., Germain, N., Jacobs, T., Frens, M. A., Diedrichsen, J., Labrecque, J., Chakravarty, M., Devenyi, G., Badura, A., Muetzel, R.

Abstract

The cerebellum has long been considered a late-maturing structure subordinate to neocortical development, therefore its potential role as an early driver of cortical organization remains largely unexplored. Using two large longitudinal neuroimaging cohorts of developing children together with lesion experiments in mice, we show that early cerebellar morphology may drive neocortical maturation in a regionally specific manner. These cross-species findings implicate the cerebellum as a possible regulator of neocortical organization.

Preprint server: bioRxiv
The authors list and abstract were imported from bioRxiv on 25 Aug 2026.

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