Non-contact optical imaging of tissue deformation enables in vivo cardiovascular monitoring

Authors

Lefebvre, A. T., Steiner, N. E., Wang, S., Rodriguez, C. L., Bar-Kochba, E., Shi, Y., Cho, S.-M., Blodgett, D. W., Mirski, M.

Abstract

Significance: Continuous, non-invasive monitoring of cardiovascular physiology provides critical information for clinical decision-making and patient care. Emerging optical sensors enable non-contact measurement of physiological parameters such as heart rate and respiratory rate, but current methods are limited in their ability to capture spatially resolved physiological waveforms. Aim: We aimed to extend the capabilities of non-contact cardiovascular monitoring by using an imaging-based approach from which spatially resolved physiological waveforms can be extracted and cardiovascular biomarkers can be derived in vivo. Approach: We implemented a digital holographic imaging sensor to continuously measure calibrated tissue motion for in vivo assessment of cardiovascular biomarkers in six adult male Sprague-Dawley rats, with validation against electrocardiographic and invasive arterial blood pressure measurements. Results: Heart rate and pulse arrival time-derived pulse wave velocity calculated from digital holographic imaging demonstrate strong agreement with reference-derived metrics (concordance correlation coefficient [≥] 0.98). Heart rate variability shows moderate agreement with reference-derived metrics (concordance correlation coefficient [≥] 0.59).

Preprint server: bioRxiv
The authors list and abstract were imported from bioRxiv on 12 Sep 2026.

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