Lasting aversive consequences of a single dose of 4-hydroxytamoxifen

Authors

Kyzar, E. J., Setara, R., Eisengart, M., Virkar, S., Rogerson, L., Ramirez, A., Salzman, C. D.

Abstract

4-hydroxytamoxifen (4-OHT) is commonly used to facilitate activity-dependent recombination in neurons. Here we show that one dose of 4-OHT devalues alcohol, contexts, and tastants, indicating that experimental designs using 4-OHT should control for its aversiveness. Further, reactivation of 4-OHT-responsive neurons causes conditioned taste avoidance. An activity screen coupled with graph theoretical analysis identifies candidate brain areas mediating these effects. We suggest these areas could be therapeutic targets for treating addiction.

Preprint server: bioRxiv
The authors list and abstract were imported from bioRxiv on 23 Sep 2026.

Stats

1-terrible, 9-excellent. How would you rate this preprint? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.