How Similar Are Two Brains? A Comprehensive Benchmark of Brain Network Similarity Measures

Authors

Dendorfer, A., Luppi, A., Poli, F., Mousley, A., Astle, D., Fakhar, K.

Abstract

A central goal of neuroscience is to establish how similar (or different) brain networks are across individuals, development, psychiatric conditions, and even between biological and artificial brains. Whenever one such comparison is made, it relies on the assumption that we have a measure that produces an accurate and plausible similarity score. Yet, the field lacks one such measure, and the wide variety of existing measures often produces conflicting results. To address this problem, we perform a systematic comparison of 16 established similarity measures. First, we show that different measures consistently disagree on which brain networks are most similar. Second, we rank all measures according to multiple criteria such as biological plausibility, computational efficiency, and sensitivity. We show that DeltaCon is the most accurate measure in terms of parameter recovery, and that it ranks among the fastest and most noise-tolerant. For this reason, we conclude that DeltaCon is the best general-purpose similarity measure. However, no measure ranks best on more than two of the five criteria we assessed, and different measures should be preferred depending on the exact research question. Measure selection can now be made on evidence and should be a crucial decision in any study that compares brain networks.

Preprint server: bioRxiv
The authors list and abstract were imported from bioRxiv on 23 Sep 2026.

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