Chemogenetic Hydrogen Sulfide Rescues Vascular Senescence in Ageing

Authors

Shabanian, K., Shabanian, T., Da Dalt, L., Colucci, M., Eroglu, E., Rodriguez Cetina Biefer, H., Dzemali, O., Hermann, M., Alimonti, A., Norata, G. D., Paneni, F., Ruschitzka, F., Saeedi Saravi, S. S.

Abstract

Vascular senescence is a central driver of whole-body ageing, yet rescue strategies remain limited. Here we show that hydrogen sulfide (H2S) bioavailability declines in ageing and atherosclerosis and is associated with endothelial senescence. Developing a novel remote-control, endothelial-specific, mitochondria-targeted chemogenetic system, we spatiotemporally controlled H2S generation and thereby mitigated endothelial senescence-driven programs and reversed vascular remodeling in aged mice.

Preprint server: bioRxiv
The authors list and abstract were imported from bioRxiv on 01 Oct 2026.

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