Spontaneous eye behavior is an objective marker of parkinsonian severity

Authors

Verma, A. K., Nandakumar, B., Feragen, Q. V., Acedillo, K., Hjelle, N., Hendrix, C. M., Duffy, K., Fiecas, M., Yu, Y., Mohanty, B., Wang, J., Vitek, J. L., Johnson, L. A.

Abstract

Eye behavior disruption is reported in Parkinson's disease (PD), but its correlation with disease severity has not been well examined. Here, in a nonhuman primate model of PD, we show that spontaneous eye behavior is impaired in parkinsonism and correlates with clinical rating scores and subthalamic beta oscillatory activity. These findings suggest that spontaneous eye behavior could serve as an objective, non-invasive biomarker of parkinsonian severity.

Preprint server: bioRxiv
The authors list and abstract were imported from bioRxiv on 01 Oct 2026.

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