Chronic Social Isolation Reshapes the Metabolome in Drosophila

Authors

Migliaccio, D., Spicer, C., Nguyen, A. D., Vora, A., Zhang, Z., Li, W.

Abstract

Sleep, feeding, and metabolism are tightly coordinated outputs of the circadian system. Previous studies showed that chronic social isolation reduces sleep and increases feeding in Drosophila. Here, untargeted metabolomic profiling revealed that chronic social isolation induces a distinct metabolomic signature spanning amino acids, carbohydrates, and lipids, establishing a foundation for understanding the physiological consequences of social isolation.

Preprint server: bioRxiv
The authors list and abstract were imported from bioRxiv on 01 Oct 2026.

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