Simulated microgravity induces aging phenotypes in human organoids

Authors

Mu, W.-C., Baechle, J., Schneider, K., Fuentealba, M., Wu, F., Manwaring-Mueller, M., Bracey, N., Chebykin, A., Saini, A., Park, J., Kim, J., Winer, D. A., Gale, A. I., Mason, C., Davis, M. M., Furman, D.

Abstract

Simulated microgravity provides a controlled perturbation for testing how loss of mechanical load affects human tissues. After 24 hours in rotating-wall vessels, neural, cardiac and tonsil organoids developed tissue-specific transcriptional responses that overlapped published spaceflight datasets, accompanied by higher transcriptomic-age estimates in neural and cardiac models, altered cardiac-organoid contraction dynamics and modified tonsil-organoid antiviral gene-expression signatures. These findings establish a multi-organoid framework for studying acute responses to gravitational unloading.

Preprint server: bioRxiv
The authors list and abstract were imported from bioRxiv on 03 Oct 2026.

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