Authors
Khan, Y. T., Tsompanidis, A., Allison, C., Bethlehem, R. A. I., Baron-Cohen, S.
Abstract
Background: Early brain structure and birth factors (e.g., sex, birth weight, gestational age at birth) are understood as critical to shaping lifelong developmental and psychopathological outcomes. Methods: Using data from the Developing Human Connectome Project, we examined whether neonatal brain volumes and birth factors predict developmental and socioemotional outcomes in toddlerhood. Structural MRI scans were acquired from 391 infants at birth (193 females, 198 males; mean age = 8 days), with follow-up behavioural assessments conducted in toddlerhood (mean age = 18 months). Results: Results demonstrated that larger neonatal brain volumes were associated with lower autistic traits and higher cognitive, language and motor outcomes. A higher gestational age and weight at birth were associated with higher scores on various of these outcomes - an effect that was partially mediated by larger brain volumes at birth. Females showed higher language scores compared to males, though this effect was suppressed rather than mediated by neonatal brain volumes. Conclusions: These findings demonstrate how birth factors interactively shape early developmental and neuropsychiatric outcomes.
Preprint server:
bioRxiv
The authors list and abstract were imported from bioRxiv on 03 Nov 2025.
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