Transcriptional perturbation effects remain structured beyond the leading global trend

Authors

Liu, Q., Zhang, Q., Chen, Y., Du, J.-H., Zhao, S., Wang, J.

Abstract

Prior work has described a global transcriptional response to gene perturbation, with many perturbations moving cells along a common direction. We find that perturbations contribute differently to this leading global trend and that substantial organization remains beyond it, including transferable perturbation-specific effects across datasets and a common hierarchy of responsive genes across perturbations. These patterns make simple strategies surprisingly competitive even in predicting effects beyond the leading global component.

Preprint server: bioRxiv
The authors list and abstract were imported from bioRxiv on 12 Oct 2026.

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